Antibacterial Polyketides from the Jellyfish-Derived Fungus Paecilomyces variotii

College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Journal of Natural Products (Impact Factor: 3.8). 07/2011; 74(8):1826-9. DOI: 10.1021/np200350b
Source: PubMed


Four new polyketides (1-4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 with MIC values in the range 5-40 μg/mL.

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    • "is fungus has been reported to possess antimicrobial activity against Enterococcus faecalis ( Olivera et al . 2009 ) . A phyto - toxin , 14 - hydroxycornexistin was isolated from this fungus and was found to be active against weeds ( Fields et al . 1996 ) . Further , polyketides isolated from Paecilomyces variotii showed antibacterial activity . ( Juan et al . 2011 ) . This is the first report on free scavenging and its effect as liver protective in CCl 4 induced hepatotoxicity of Paecilomyces variotii . The activity of TRF - 1 may be attributed to the secondary metabolites of fungus Paecilomyces variotti Bain which are yet to be explored ."
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