Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1)

Department of Chemistry, University of Puerto Rico, P.O. Box 23346, UPR Station, San Juan, 00931-3346 (Puerto Rico).
Angewandte Chemie International Edition (Impact Factor: 11.26). 08/2011; 50(35):8134-8. DOI: 10.1002/anie.201102546
Source: PubMed


A bidirectional affinity system has been developed for the identification of cancer-related natural products and their biological targets. Aplysqualenol A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small-molecule isolation and target identification can be conducted using conventional molecular biological methods.

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