1156 | WYNN ET AL. | MOL MED 17(11-12)1146-1156, NOVEMBER-DECEMBER 2011
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ways do not yield specific pathophysiol-
ogy. However, these data do offer insight
into the complex, multifactorial heteroge-
neous host response to sepsis and allow
identification of critical differences be-
tween age groups.
Children are not small adults, and, in
the host response to sepsis, we show that
neonates are not small children. Age-spe-
cific neonatal and pediatric studies of the
host response to sepsis are critically nec-
essary to permit identification of novel,
developmentally appropriate transla-
tional opportunities that might lead to
improved sepsis outcomes.
This study was supported by grants
from the National Institutes of Health
(R01GM064619 and RC1HL100474).
The authors wish to thank Dr. Philip
O. Scumpia for his careful review of the
manuscript and comments.
The authors declare that they have no
competing interests as defined by Molecu-
lar Medicine, or other interests that might
be perceived to influence the results and
discussion reported in this paper.
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