Informatics and standards for nanomedicine technology

Knowledge Discovery and Informatics Group, Pacific Northwest National Laboratory, Richland, WA, USA.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology (Impact Factor: 4.49). 09/2011; 3(5). DOI: 10.1002/wnan.152
Source: PubMed


There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration; data sharing; unambiguous representation and interpretation of data; semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this article, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, because of gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret, and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, and so on. Progress toward resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this article will be essential to the rapidly growing field of nanomedicine informatics. WIREs Nanomed Nanobiotechnol 2011 DOI: 10.1002/wnan.152 This article is a U.S. Government work, and as such, is in the public domain in the United States of America. For further resources related to this article, please visit the WIREs website.

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    • "Different types of information are stored in the database: particles' size, size distribution, zeta potential, aggregation properties, purity, etc. Importantly, a great importance is given for (i) quality control of data before their actual integration to the repository, (ii) consistency of MNPs' naming and description ontology, (iii) storing protocols for enabling proper data sharing according to Nano-Tab (D. G. Thomas, Pappu, and Baker 2011; D. G. Thomas et al. 2011) recommendations. "
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    Full-text · Chapter · Mar 2014
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    • "The use of novel, “visual” nano-ontologies could provide greater semantic content, together with research on more advanced methods of text mining from the literature. As mentioned, the choice of unique material identifiers is an important subtopic of ongoing research by the new Nanomaterials Registry supported jointly by the NCI, the National Institute of Environmental Health Sciences, and the National Institute of Biomedical Imaging and Bioengineering.70 The registry has developed a prototype database and user interface and initial datasets are being curated.71 "
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    ABSTRACT: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and -omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings.
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