Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene Suppl 2:S31-S42

Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4330, USA.
Oncogene (Impact Factor: 8.46). 12/2008; 27 Suppl 2(Suppl. 2):S31-42. DOI: 10.1038/onc.2009.351
Source: PubMed


The study of acute-transforming retroviruses and their oncogenes and of the multiple mechanisms deployed by DNA viruses to circumvent the growth-suppressive and proapoptotic function of tumor suppressor genes has provided the foundation of our current understanding of cancer biology. Unlike acute-transforming animal viruses, however, human tumor-associated viruses lead to malignancies with a prolonged latency and in conjunction with other environmental and host-related cooperating events. The relevance of viral infection to human cancer development has often been debated. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Hence, the opportunity exists to fight cancer at the global scale by preventing the spread of these viruses, by the development and distribution of effective and safe antiviral vaccines, and by identifying their oncogenic mechanism. Here, we discuss the molecular events underlying the neoplastic potential of the human tumor-associated viruses, with emphasis on the enigmatic KSHV and its numerous virally hijacked proangiogenic, immune-evasive and tumor-promoting genes. The emerging information may facilitate the development of new molecular-targeted approaches to prevent and treat virally associated human malignancies.

  • Source
    • "Viral and bacterial infections are strongly related to human carcinogenesis, and viral infections account for 10– 15 % of human cancers worldwide[1,2]. Infectionassociated cancers (Table 1) include hepatocellular carcinomas (HCCs) induced by the hepatitis B virus (HBV) and hepatitis C virus (HCV)345; lymphomas, nasopharyngeal cancers (NPCs), and gastric cancers associated with the Epstein-Barr virus (EBV)[6,7]; cervical and head and neck squamous cell cancers (HNSCCs) induced by human papillomavirus (HPV)[8,9]; Merkel cell carcinoma associated with Merkel cell polyomavirus (MCPyV)[10,11]; and gastric cancers induced by Helicobacter pylori[12]. The carcinogenic mechanisms of these infection-associated cancers have been extensively investigated, focusing on the effects of viral and bacterial infections and the resultant inflammation on cell proliferation , cell signaling, and genetic alterations[1]. "

    Preview · Article · Dec 2016 · Genome Medicine
  • Source
    • "R.Y.L. Wang et al. / Virology 443 (2013) 236–247 242 of HCV, playing a key role in the initiation of viral replication (Okamoto et al., 2006, 2008). In addition, Hsp90 participates in transcriptional regulation of oncogenic viral genes of Epstein-Barr virus (EBV) and gamma-herpesvirus, resulting in the regulation of cell signaling pathways (Elgui de Oliveira, 2007; Martin and Gutkind, 2008). In the case of EBV, Hsp90 promotes the LMP-1- induced Akt phosphorylation, resulting in the suppression of apoptosis in EBV-infected lymphoma cells (Jeon et al., 2007), and modulates the expression of EBNA1, an EBV-encoded viral protein that is involved in many EBV functions, including gene regulation, Fig. 5. Pharmacological inhibition of Hsp90β-VPs binding and EV71 assembly. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Molecular chaperones are reported to be crucial for virus propagation, but are not yet addressed in Human Enterovirus 71 (EV71). Here we describe the specific association of heat shock protein-90-beta (Hsp90β), but not alpha form (Hsp90α), with EV71 viral particles by the co-purification with virions using sucrose density gradient ultracentrifugation, and by the colocalization with viral particles, as assessed by immunogold electron microscopy. The reduction of the Hsp90β protein using RNA interference decreased the correct assembly of viral particles, without affecting EV71 replication levels. Tracking ectopically expressed Hsp90β protein associated with EV71 virions revealed that Hsp90β protein was transmitted to new host cells through its direct association with infectious viral particles. Our findings suggest a new antiviral strategy in which extracellular Hsp90β protein is targeted to decrease the infectivity of EV71 and other enteroviruses, without affecting the broader functions of this constitutively expressed molecular chaperone.
    Preview · Article · May 2013 · Virology
  • Source
    • "Regarding HPV, more than 130 HPV types have been identified and are classified into low-and high-risk groups depending on their likelihood of inducing cervical cancer [12]. Of the individuals infected with HPV, 10–20% will develop cancer of the cervix, anus, vulva, penis and of the head and neck area and oropharynx [1] [4] [13]. HPV is associated with nearly all the carcinomas of the uterine cervix with 70% of the cervical cancers associated with the high-risk HPV types 16 and 18 [12]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Oncovirus, synonymously called a 'tumour virus', is a virus that can cause cancer. An oncolytic virus preferentially infects the host's cancer cells and lyses them, causing tumour destruction, and is thus referred to as a 'cancer killing virus'. With an estimated 11% of cancer-associated deaths caused by oncoviruses and the possibility that many cancers may be treated by using oncolytic viruses, the role of viruses in cancer may be viewed as a double-edged sword. A total of seven human cancer viruses have been identified as oncoviruses, having been associated with various cancers. Conversely, a large number of oncolytic viruses have shown great potential towards the treatment of certain types of cancer. Proteomics has now been applied towards understanding the complex interplay that exists between oncoviruses and the immune responses that serve to prevent oncoviral diseases. This review attempts to summarise the neoplastic potential of human tumour associated viruses and associated vaccine successes. The potential use of oncolytic viruses for the therapeutic intervention of cancer will also be discussed. Finally, this review will discuss the enormous potential of proteomics technology in the field of oncovirology.
    Full-text · Article · Jul 2012 · Proteomics
Show more