Article

Cohen JI, Bollard CM, Khanna R, et al. Current understanding of the role of Epstein-Barr virus in lymphomagenesis and therapeutic approaches to EBV-associated lymphomas.

Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA.
Leukemia & lymphoma (Impact Factor: 2.89). 01/2008; 49 Suppl 1(1):27-34. DOI: 10.1080/10428190802311417
Source: PubMed

ABSTRACT

A heterogeneous group of malignancies are associated with Epstein-Barr virus (EBV) infection. These malignancies arise in both immunosuppressed and immunocompetent individuals and can be divided into three patterns of latency depending on the viral genes that are expressed. In Type III latency malignancies, such as post-transplant lymphoproliferative disorder (PTLD), EBV has a direct role and the activated B-cell phenotype is characterised by high-level expression of all the immunodominant EBV latency proteins. Thus, EBV-infected B cells are good targets for EBV-specific cytotoxic T lymphocytes (CTLs). New immune-based treatments for PTLD include transfer of ex vivo generated autologous EBV-specific CTLs or, in the case of bone marrow transplant recipients, donor-derived EBV-specific T cells. This strategy could, perhaps, also work in Type II latency malignancies, where EBV acts like a cofactor rather than having a direct role. In initial studies, T cells specific for the weakly immunogenic latent membrane protein 2 have been expanded ex vivo and have promoted tumor regression in a subset of patients. Another potential therapeutic strategy could be to try to induce lytic EBV infection in the tumor cells. This could be done by targeting genes that switch the EBV-infected B cells from the latent to the lytic cycle.

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Available from: Catherine M Bollard, Jun 18, 2015
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    • "Clinical manifestations of EBV infections vary according to age, ranging from silent infections in infants to infectious mononucleosis in adolescents and adults. In addition, many serological and molecular studies have provided evidence that EBV is associated with various types of malignancies such as lymphoma, nasopharyngeal carcinoma (NPC), Hodgkin disease and gastric carcinoma (Cohen et al., 2008; Hjalgrim et al., 2000; Mitarnun et al., 2004; Piriou et al., 2012; Tiwawech et al., 2005). The seroprevalence of EBV antibodies increases with age but varies across populations according to geographic region, ethnicity and socioeconomic status (Balfour et al., 2013 ; Condon et al., 2014 ; Dowd et al., 2013 ; Kagro et al., 1994 ). "
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    • "Recently, the association between synchronous gastric adenocarcinoma and primary gastric lymphoma was found to be related to infection by H. pylori [12]. EBV is also related to some types of lymphoma, nasopharyngeal carcinoma, and certain forms of gastric carcinoma [13]. However, H. pylori was not detected and EBV was only found in HL but not in the gastric adenocarcinoma in our patient. "
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