Article

Assessing the future of diffuse optical imaging technologies for breast cancer managment

Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA.
Medical Physics (Impact Factor: 2.64). 06/2008; 35(6):2443-51. DOI: 10.1118/1.2919078
Source: PubMed

ABSTRACT

Diffuse optical imaging (DOI) is a noninvasive optical technique that employs near-infrared (NIR) light to quantitatively characterize the optical properties of thick tissues. Although NIR methods were first applied to breast transillumination (also called diaphanography) nearly 80 years ago, quantitative DOI methods employing time- or frequency-domain photon migration technologies have only recently been used for breast imaging (i.e., since the mid-1990s). In this review, the state of the art in DOI for breast cancer is outlined and a multi-institutional Network for Translational Research in Optical Imaging (NTROI) is described, which has been formed by the National Cancer Institute to advance diffuse optical spectroscopy and imaging (DOSI) for the purpose of improving breast cancer detection and clinical management. DOSI employs broadband technology both in near-infrared spectral and temporal signal domains in order to separate absorption from scattering and quantify uptake of multiple molecular probes based on absorption or fluorescence contrast. Additional dimensionality in the data is provided by integrating and co-registering the functional information of DOSI with x-ray mammography and magnetic resonance imaging (MRI), which provide structural information or vascular flow information, respectively. Factors affecting DOSI performance, such as intrinsic and extrinsic contrast mechanisms, quantitation of biochemical components, image formation/visualization, and multimodality co-registration are under investigation in the ongoing research NTROI sites. One of the goals is to develop standardized DOSI platforms that can be used as stand-alone devices or in conjunction with MRI, mammography, or ultrasound. This broad-based, multidisciplinary effort is expected to provide new insight regarding the origins of breast disease and practical approaches for addressing several key challenges in breast cancer, including: Detecting disease in mammographically dense tissue, distinguishing between malignant and benign lesions, and understanding the impact of neoadjuvant chemotherapies.

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Available from: Albert Cerussi, Sep 04, 2014
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    • "DOS allows the non-invasive characterization of the wavelength dependent absorption and scattering properties of tissues from which the microvascular total hemoglobin concentration (THC), blood oxygen saturation (StO 2 ) and the concentration of water, lipids and other tissue chromophores can be derived. It has been widely applied in characterizing tumor tissues, specially in optical mammography, and for the monitoring of the local tissue response to ther- apy222324. Diffuse correlation spectroscopy (DCS)[19,25,26]is another related technique which allows the direct measurement of the deep local microvascular blood flow[27]. DCS hascollection and analysis, decision to publish, or preparation of the manuscript. "
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    • "See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. with magneto-fluorescent nanoparticles has been proposed in conjunction with FMT [20]–[24]. While FMT can benefit from the excellent soft-tissue contrast of MRI, realization of hybrid FMT-MRI systems is limited due to several technical challenges [23], [25], [26]. "
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    • "Fiber-coupled illumination and photo-detection have been adopted since the very early stage of development of diffuse optics and are still being widely used. It can be found in diffuse optical tomography (DOT), fluorescence diffuse optical tomography (FDOT), and near infrared spectroscopy (NIRS) of the human brain [12, 13, 14], human breast [15, 16, 17], and small animals [18, 19, 20, 21]. The fiber optics can be in direct contact with the surface of imaging subject or in indirect contact via optical matching fluid. "
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