The bla CTX-M-1 gene located in a novel complex class I integron bearing an ISCR1 element in Escherichia coli isolates from Zhenjiang, China

Journal of Antimicrobial Chemotherapy (Impact Factor: 5.31). 11/2008; 62(5):1150-1. DOI: 10.1093/jac/dkn300
Source: PubMed

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    • "The second most prevalent genetic element associated with bla CTX-M genes is the ISCR1 element, formerly known as the orf513-common region, which is normally found within the backbone of unusual or complex class 1 integrons [177] [178]. The ISCR1 element is usually located upstream of bla CTX-M genes and has been found associated with bla CTX-M-2, and bla CTX-M-59 from group 2 [71] [179] [180] [181] [182], (GenBank EU622856) and bla CTX-M-9 and bla CTX-M -14 from group 9 [178] [183] [184] [185], and bla CTX-M-1 from group 1 [186]. Structures harboring ISCR1-associated integrons are usually related to Tn402 derivatives, and sometimes linked with Tn21 or Tn1696 transposons. "
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