BAFF is elevated in serum of patients with psoriasis: Association with disease activity
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Available from: Koichi Yanaba
- "Serum BAFF levels are reported to be elevated in autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. In the present study, serum BAFF levels were significantly higher in patients with psoriasis than in healthy controls, as reported previously. Recent investigations have shown that BAFF enhances IL-10 secretion from murine CD1d hi CD5 + B10 progenitor cells in vitro. Moreover, BAFF has also been shown to augment IL-10 production from human blood B cells, suggesting that BAFF may encourage B10 progenitor cells to produce IL-10. "
Available from: Ming Guan
- "In addition, ANA was found in patients with PsA and cutaneous psoriatic forms. Disease severity in patients with psoriasis was correlated with the serum levels of BAFF (Samoud-El Kissi et al., 2008). BAFF was identified as a potent B-cell stimulatory molecule associated with systemic autoimmune diseases including systemic lupus erythematosus and Sjö gren's syndrome (Matsushita & Sato, 2005; Moisini & Davidson, 2009). "
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ABSTRACT: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This study aimed to determine the association between three functional SNPs of BANK1 (rs10516487, rs17266594 and rs3733197) with psoriasis in Southern Han Chinese population by determining their frequency in 242 patients with psoriasis and 317 healthy individuals. The genotype frequencies of the detected polymorphisms were analysed in relation to the susceptibility of psoriasis. Our data show that there is no significant difference in genotype distribution for the three BANK1 SNPs between patients and healthy controls. The AA frequency of rs3733197 is significantly higher in patients with psoriasis onset before the age of 23 than in those with late disease onset (P = 0.0069). In addition, analysis on BANK1 haplotype also suggests a protective role for TGC and CAT haplotype from psoriasis (OR 0.55, 95% CI: 0.34-0.89; P = 0.0144; OR 0.62, 95% CI: 0.42-0.92; P = 0.0175), whereas CGT haplotype is associated with increased risk of the disease (OR 1.38, 95% CI: 1.05-1.81, P = 0.0203). Overall, our result indicates that polymorphism in BANK1 is associated with susceptibility to psoriasis in Southern Han Chinese.
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ABSTRACT: The 67th Annual Meeting of the American Academy of Dermatology took place in San Francisco on 6-10 March 2009. The flavour of this busy but well-organized convention was a mixture of practical, hands-on teaching sessions, led and delivered by experts, with breakthrough cutting-edge scientific sessions. Aesthetic dermatology comprised a significant part of the meeting. It is impossible to encompass all the important presentations made at the meeting and satellite symposiums, but we highlight here a few medical pearls on dermoscopy, melanoma and oncology, inflammatory dermatoses and community-acquired methicillin-resistant Staphylococcus aureus. Our report is not intended as a substitute for reading the conference proceedings, educational session handouts, online updates and related references quoted in this article.
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