Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats

Department of Clinical Sciences, Malmö University Hospital, Malmö, Sweden.
Neuroreport (Impact Factor: 1.52). 06/2008; 19(9):987-90. DOI: 10.1097/WNR.0b013e328302f4ec
Source: PubMed


Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.

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    • "Furthermore, animal experiments have shown that the Schwann cells around the axons also are affected by the compression. Experimental studies have shown that the response is more pronounced in both neurons and Schwann cells in diabetic animals than in healthy ones [23]. The intracellular transport in the axon, i.e. axonal transport, provides the distal part of the nerve with essential substances as well as conveying information from the periphery up to the nerve-cell body. "
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    • "ATF3 is strongly upregulated in peripheral glia following various types of injury. Schwann cells in the distal stump of injured sciatic nerves in rats and mice upregulate ATF3 (Hunt et al., 2004; Isacsson et al., 2005; Kataoka et al., 2007; Dahlin et al., 2008; Saito and Dahlin, 2008) in addition to c-Jun. Glial cells including Schwann and satellite cells in the superior cervical ganglion expressed ATF3 after decentralization (section of the cervical sympathetic trunk); this procedure induces the anterograde degeneration of preganglionic fibers and some of the ATF3 expression was probably around degenerating fibers (Zigmond and Vaccariello, 2007). "
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    Full-text · Article · Feb 2012 · Frontiers in Molecular Neuroscience
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    • "In contrast with Wright et al,42 a study by Dahlin et al44 concluded that diabetes does not in itself cause an increase in ATF3 expression, but it does enhance the expression of ATF3 in response to nerve injury. To investigate whether the higher ATF3 expression seen in DRG cultures from diabetic rats is not just due to a higher vulnerability of the neurons to the isolation procedure, we undertook an RT-PCR analysis of whole-mounted DRGs for the stress-related genes, ATF3, c-jun, and c-fos. "
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