Anton RF. Genetic basis for predicting response to naltrexone in the treatment of alcohol dependence. Pharmacogenomics 9: 655-658

Pharmacogenomics (Impact Factor: 3.22). 06/2008; 9(6):655-8. DOI: 10.2217/14622416.9.6.655
Source: PubMed

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    • "This issue is highly salient in light of the recent attempt byOslin et al. (2015)to show an effect of the OPRM1 variant As- n40Asp in treatment response to naltrexone. Previous retrospective pharmacogenetic analyses of this SNP have robustly demonstrated that the Asp40 allele was predictive of reduced relapse rates and lower drinking rates in alcohol-dependent individuals treated with naltrexone compared to the Asn40Asn group (Anton, 2008;Chen et al., 2013;Kranzler et al., 2013a;Oslin et al., 2003). However,Oslin et al. (2015)failed to find a significant genotype  treatment interaction in their sample, suggesting that " it is premature to use the Asn40Asp polymorphism as a biomarker to predict the response to naltrexone treatment of alcohol dependence " (Oslin et al., 2015). "
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