Article

Glassy cell carcinoma of the endometrium: A case report and review of the literature

Catholic University of the Sacred Heart , Milano, Lombardy, Italy
Pathology - Research and Practice (Impact Factor: 1.4). 04/2007; 203(4):217-20. DOI: 10.1016/j.prp.2007.02.001
Source: PubMed

ABSTRACT

Glassy cell carcinomas are composed of malignant cells showing a "ground glass" cytoplasm, distinct cell membranes, and large nuclei with prominent nucleoli. To our knowledge, only 12 cases of glassy cell endometrial carcinomas (EGCC) have been reported until now. A 63-year-old patient complaining of irregular vaginal bleeding underwent hysteroscopy-guided biopsy revealing a well-differentiated endometrial endometrioid adenocarcinoma. The patient underwent left salpingo-oophorectomy, total abdominal hysterectomy, and pelvic lymphadenectomy. The final diagnosis was FIGO stage IB poorly differentiated endometrial adenosquamous carcinoma with > 90% of glassy tumor cells. The patient is alive, with no evidence of disease for 69 months after diagnosis. We describe an additional case of EGCC and review the data of the literature, emphasizing the need to strictly define the criteria for the diagnosis and the potential usefulness of assessing biologic parameters for the prognostic characterization of this rare entity.

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    ABSTRACT: RESUMEN Glassy cell es una rara neoplasia maligna que representa una forma poco diferenciada del carcinoma adenoescamoso. Se ha descrito más frecuentemente en cáncer cervicouterino y de endometrio. En cáncer de vagina presentamos el segundo caso reportado en la literatura. ABSTRACT Glassy cell is a rare malignant neoplasm that represents a poorly differentiated form of adenosquamous carcinoma. It has been described more frequently in cervical and endometrial cancer. In cancer of vagina we are presenting the second case reported in the literature. INTRODUCCIÓN E l cáncer de vagina (CV) representa aproximada mente el 2% de todas las neoplasias malignas del tracto genital femenino 1. En Estados Unidos se diagnostican 2.420 casos nuevos y fallecen 820 mujeres anualmente 2. La supervivencia global en CV no ha mejorado durante las últimas décadas y se han reportado cifras a los 3 y 5 años de 59% y 52% respectivamente 3. En el 2005, el MD Anderson de Houston publica su experiencia en 193 casos de CV. La supervivencia encontrada en estadio I fue del 85% versus 58% en los estadios III-IVA 4. De acuerdo a la recomendaciones de la Federa-ción Internacional de Ginecología y Obstetricia (FIGO) previo al diagnóstico de CV se debe descartar la presencia de cáncer cervicouterino, uretral y de vulva 3. El carcinoma escamoso representa aproximada-mente el 90% de los tumores primarios de vagina y el adenocarcinoma representa cerca del 9% 5. La variante histológica glassy cell representa una forma poco diferenciada del carcinoma adenoesca-moso. A la microscopía se caracteriza por presentar células grandes. El citoplasma tiene apariencia granu-lar y en algunas ocasiones, se aprecia infiltración inflamatoria estromal compuesta predominantemente de eosinófilos y células plasmáticas (Figura 1A). Fue descrito por primera vez en cérvix por Glucksmann y Cherry 6. Representa el 1% del cáncer cervicouterino y se caracteriza por ser muy agresi-vo 7,8. En endometrio se han publicado sólo 12 casos y representa el 0,5% de los carcinomas endometria-les 9 ,10 .
    Full-text · Article · Jan 2008
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    ABSTRACT: Glassy cell carcinoma is a rare neoplasm that occurs most frequently in the uterine cervix. We describe the first reported case of glassy cell carcinoma arising in the vagina. A 77-year-old Japanese woman was admitted to our hospital for atypical genital bleeding. Gynecological examination revealed a macroscopic vaginal cancer of 1.5 cm in diameter located in the upper 1/3 of the vagina. The pathological diagnosis of the biopsied specimen was glassy cell carcinoma. She was successfully treated by conventional radiation therapy and chemotherapy under the diagnosis of stage I vaginal cancer (International Federation of Gynecologists and Obstetricians classification, 1986). The patient is alive, without evidence of recurrence, 21 months following the radiation therapy. Glassy cell carcinoma is classified as the most poorly differentiated form of adenosquamous carcinoma. The present case illustrates the potential for glassy cell carcinoma to arise in the Mullerian epithelium throughout the female genital tract.
    No preview · Article · Feb 2008 · Acta Obstetricia Et Gynecologica Scandinavica
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    ABSTRACT: The authors presented a case of a 68-year-old woman with glassy cell carcinoma of the endometrium in FIGO stage IA, treated with hysterectomy, bilateral salpingo-oophorectomy and radiation therapy. The patient was alive and disease free at the end of 2 years of follow up. Glassy cell carcinoma of the endometrium is a rare neoplasm, with 13 previously cases reported in the literature. Although glassy cell carcinoma is considered to be a poor differentiated variant of adenosquamous carcinoma, its real nature is still debated. In order to establish correct prognosis for this rare entity and to evaluate the nature and clinical significance of glassy cell carcinoma detailed analysis of more cases is required.
    No preview · Article · Jul 2009 · Orvosi Hetilap
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