Cadmium toxicity in growing swine

Journal of Nutrition (Impact Factor: 3.88). 07/1973; 103(7):964-72.
Source: PubMed


Cadmium (Cd) as cadmium chloride was added to the basal diet of 8-week-old swine at levels of 0, 50, 150, 450 and 1350 ppm for a 6-week comparison period. Growth rate was decreased as a function of Cd level, having ceased in the 1350 ppm group. Hematocrit values were the most sensitive measurement of toxicity and were decreased in all Cd-fed animals. Serum phosphorus was decreased in animals receiving 450 and 1350 ppm Cd, while serum calcium was not affected by Cd intake. Bone ash content was decreased as a function of Cd intake. Leucine aminopeptidase (LAP) activity was depressed in renal cortex from the groups receiving 150 ppm Cd or more, but serum LAP was unaffected by Cd intake. The kidney, liver, spleen and teeth contained the highest concentrations of Cd. Kidney Cd increased with dietary Cd level but appeared to reach a near maximal level in the 450 and 1350 ppm Cd groups. This renal Cd content was directly related to the level of cadmium-binding protein isolated from kidney cortex by gel filtration chromatography. 30 references, 2 figures, 6 tables.

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    • "There is a report that MT subsists in a very low density under normal circumstances, but the MT amount grows when the synthesis is promoted by metals like Cd or Pb in organs such as liver (Nordberg & Nordberg, 1987). MT can be synthesized anywhere inside the body but mostly in the liver and kidney, and can be combined with Cd, which prevents free reactive Cd from making to the body which makes toxic materials (Cousins et al., 1973). The half-life of MT differs to the metal it combines with, but is rather short from 1 to 4 days, so the MT must be combined endlessly to counteract poison made by Cd or heavy metals (Revis & Osborne, 1984). "
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    • "Pulmonary absorption of Cd is relatively more efficient than the absorption of Cd along the gastrointestinal tract. It has been shown that the efficiency of gastrointestinal absorption of Cd is only about 1–2% in mice and rats (Decker et al., 1958; Ragan 1977), 0.5–3% in monkeys (Nordberg et al., 1971), 2% in goats (Miller et al., 1969), and 5% in pigs and lambs (Cousins et al., 1973; Doyle et al., 1974). Among most species of mammals studied, the efficiency of gastrointestinal absorption of Cd appears to be greatest (nearly 16%) in cattle (Miller et al., 1969). "
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