Simple Determination of Double-Bond Positions in Long-Chain Olefins by Cross-Metathesis

College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742 (Korea), Fax: (+82) 2-888-0649.
Angewandte Chemie International Edition (Impact Factor: 11.26). 08/2011; 50(36):8275-8. DOI: 10.1002/anie.201102634
Source: PubMed


Cut, paste, and measure: The positions of double bonds in unsaturated long-chain compounds can be easily determined by chemical derivatization using a cross-metathesis reaction and chromatography-mass spectrometry. The produced olefins have distinct physicochemical properties suitable for LC/MS or GC/MS analysis that depend on the cross-metathesis partner used. This method is operationally simple and applicable at a sub-milligram scale.

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