Dermocosmetics for Dry Skin: A New Role for Botanical Extracts

Article (PDF Available)inSkin pharmacology and physiology 24(6):289-93 · June 2011with478 Reads
DOI: 10.1159/000329214 · Source: PubMed
Dry skin is associated with a disturbed skin barrier and reduced formation of epidermal proteins and lipids. During recent years, skin-barrier-reinforcing properties of some botanical compounds have been described. Searching the PubMed database revealed 9 botanical extracts that specifically improve skin barrier and/or promote keratinocyte differentiation in vivo after topical application. The topical application of Aloe vera (leaf gel), Betula alba (birch bark extract), Helianthus annuus (sunflower oleodistillate), Hypericum perforatum (St. John's wort extract), Lithospermum erythrorhizon (root extract), Piptadenia colubrina (angico-branco extract) and Simarouba amara (bitter wood extract) increased skin hydration, reduced the transepidermal water loss, or promoted keratinocyte differentiation in humans in vivo. The topical application of Rubia cordifolia root extract and rose oil obtained from Rosa spp. flowers stimulated keratinocyte differentiation in mouse models. The underlying mechanisms of these effects are discussed. It is concluded that some botanical compounds display skin-barrier-reinforcing properties that may be used in dermocosmetics for dry skin. However, more investigations on the mode of action and more vehicle-controlled studies are required.

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Available from: Ute Woelfle, Jul 28, 2014
    • "Helianthus annuus is widely grown as commercial crop, whole plant and leaf extracts has been traditionally used as antiinflammatory , anti-tumor agent and antibacterial agents (Rajakannu and Sritharan, 2012; Ukiya et al., 2003; Sechi et al., 2001). The sunflower oil (Oleozon) extracted from flowers has been used as food and an additive of drug and cosmetic formulations (Casetti et al., 2011). All these medical herbs have been documented and studied for its phytochemical constituents. "
    [Show abstract] [Hide abstract] ABSTRACT: In the current investigation the traditional aqueous and ethanolic extraction products from leaves of Sphaeranthus indicus and flowers of Helianthus annus were evaluated for antibacterial activity against multi drug resistant (MDR) bacterial isolates from the clinical samples. Standard tube dilution and disc diffusion methods were employed to assess the antibacterial activity. The results showed, ethanolic sphaeranthus extract at a minimum inhibitory concentration (MIC) of 3mg/ml by tube dilution & 1.8 mg/ml by disc diffusion method inhibited the growth of MDR Staphylococcus and Klebsiella. Further the MDR E.coli and pseudomonas were effectively inhibited by the ethanolic extract of Helianthus at a concentration of 4 mg/ml and 2.5 mg/ml by tube dilution and disc diffusion methods respectively. The aqueous extracts of both the herbs showed a transient antibacterial activity against MDR staphylococcus isolate, while there was no observable activity against MDR E.coli, pseudomonas or klebsiella isolates. Collectively targeting the MDR isolates may pave a way for future class of drugs from natural products in way they have been extracted and used for generations.
    Full-text · Article · Jan 2016 · Revista Brasileira de Farmacognosia
    • "It has been proved to be a relatively safe herb in addition to being economical and easily applied (Sudarshan et al., 2012). It has also been recommended for the management of dry skin (Casetti et al., 2011) as well as dry mouth (Momm et al., 2005). The latter study found that a gel saliva substitute based on Aloe vera led to a marked improvement of the quality of life and reduced significantly the frequency of salivary substitute use (Momm et al., 2005). "
    [Show abstract] [Hide abstract] ABSTRACT: Persistent xerostomia may be encountered in a substantial number of patients particularly head and neck cancer patients who received radiation, and patients with Sjogren's syndrome. Unfortunately many of these patients have lost all salivary function due to the irreversible destruction of salivary gland parenchyma. Management of this problem becomes palliative and requires the administration of salivary substitutes. This review considers the evidence regarding natural salivary substitutes that may be used to relieve severe dry mouth associated with irreversible damage of salivary glands.
    Article · May 2015
    • "Simaba ferruginea showed antiulcerogenic activity by gastroprotection (Almeida et al., 2011). The aqueous extract of Simarouba amara promoted the differentiation of human skin keratinocytes and increased the production of involucrin, cholesterol and ceramides as well thus it may be used for dry skin as it also improves water retention by the stratum corneum (Bonté et al., 1996; Casetti et al, 2011). Due to these findings, a patent was registered in 1997 for cosmetic or pharmaceutical use for the skin (Bonté et al., 1997). "
    [Show abstract] [Hide abstract] ABSTRACT: The Simaroubaceae family includes 32 genera and more than 170 species of trees and brushes of pantropical distribution. The main distribution hot spots are located at tropical areas of America, extending to Africa, Madagascar and regions of Australia bathed by the Pacific. This family is characterized by the presence of quassinoids, secondary metabolites responsible of a wide spectrum of biological activities such as antitumor, antimalarial, antiviral, insecticide, feeding deterrent, amebicide, antiparasitic and herbicidal. Although the chemical and pharmacological potential of Simaroubaceae family as well as its participation in official compendia; such as British, German, French and Brazilian pharmacopoeias, and patent registration, many of its species have not been studied yet. In order to direct further investigation to approach detailed botanical, chemical and pharmacological aspects of the Simaroubaceae, the present work reviews the information regarding the main genera of the family up to 2013.
    Full-text · Article · Aug 2014
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