Does Increased Intake of Salmon Increase Markers of Oxidative Stress in Pregnant Women? The Salmon in Pregnancy Study

Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
Antioxidants & Redox Signaling (Impact Factor: 7.41). 06/2011; 15(11):2819-23. DOI: 10.1089/ars.2011.4108
Source: PubMed


The Salmon in Pregnancy Study provided two meals of salmon per week to pregnant women from week 20 of gestation; the control group maintained their habitual diet low in oily fish. Salmon is a rich source of marine n-3 fatty acids. Since marine n-3 fatty acids may increase oxidative stress, we investigated whether increased salmon consumption could affect markers of oxidative stress in mid and late pregnancy. Urinary 8-iso-prostaglandin F(2α), urinary 8-hydroxy-2'-deoxyguanosine, and plasma lipid peroxide concentrations did not change from week 20 to 38 of pregnancy and were not altered by increased consumption of salmon. Thus, increased intake of salmon during pregnancy does not increase oxidative stress, as judged by the markers of oxidative damage to lipids and DNA measured herein.

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Available from: Cruz E García-Rodríguez, Nov 19, 2014
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    • "However, the present study of daily supplementation of 2.3 g of ω-3 FAs for six months could not demonstrate such properties, indicating that ω-3 FAs do not necessarily increase auto-oxidation or in vivo lipid oxidation. This issue was also addressed in a study of pregnant British women [43] who ingested salmon equivalent to about 500 mg of LC-PUFA twice weekly, without any significant effects on the different oxidation markers. A major limitation of the present study is the absence of a healthy reference group to compare with the study population. "
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