Natural product-like synthetic libraries

Institute of Chemical and Engineering Sciences, Organic Chemistry, 11 Biopolis Way, Helios, Singapore 138667, Singapore.
Current opinion in chemical biology (Impact Factor: 6.81). 06/2011; 15(4):516-22. DOI: 10.1016/j.cbpa.2011.05.022
Source: PubMed


There is a paucity of chemical matter suitably poised for effective drug development. Improving the quality and efficiency of research early on in the drug discovery process has been a long standing objective for the drug industry and improvements to the accessibility and quality of compound screening decks might have a significant and positive impact. In the absence of specific molecular information that can be modeled and used predicatively we are far from identifying which small molecules are most relevant to emerging biological targets such as protein-protein interactions. Natural products have been historically successful as an entry point for drug discovery and recently screening libraries are being synthesized to emulate natural product like features.

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