Introduction:Excess visceral adipose tissue (VAT) is one of the most deleterious fat depots in the body, with strong links to 1,2cardiovascular disease and certain types of cancer. Lipid accumulation product (LAP) index, a recently developed biomarker of central fat accumulation, has been recommended as a precise indicator of the risk of insulin resistance, metabolic syndrome, type 2 diabetes, and 3-5cardiovascular disease. Higher LAPhas have been associated with abnormal glucose homeostasis and insulin resistance, as well as elevated alanine aminotransferase in healthy 6 individuals. A Chinese study showed that both LAPand visceral adiposity index (VAI) were effective markers for 7 stratifying adults for obesity phenotypes.In addition,Abstract Background: Diabetes Mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from deficiency of insulin secretion, action, or both. Globally, type 2 diabetes mellitus (T2DM) is considered one of the most common diseases. Dietary habits and sedentary lifestyles are the major factors for the rapidly rising incidence of DM among developing countries. Objective: This study was carried out with an objective to evaluate the association between visceral adiposity index(VAI) and dietary patterns regarding fast food-taking habits in T2 DM patients in Bangladesh.Methods:This case-control study was performed from 2015 to 2017 in BIRDEM with 700 study subjects aged 30 to 60 years. Out of which 350 were T2DM and 350 were healthy control. Cases were selected from the outpatient department of BIRDEM, and controls were selected from healthy workers and employees of BIRDEM & IMC. We evaluated waist & hip circumference, BMI, systolic and diastolic blood pressure, fast food taking the history, exercise history using a preset questionnaire. Serum fasting glucose, ABF, TAG, Total cholesterol, HDL-C, LDL-C, HbA1c, and Serum insulin were estimated according to a standardized method and by calculation method HOMAIR, HOMAB, Secretory-HOMA& VAI were estimated. Results: There were significant differences in mean age, BMI, waist circumferences, hip circumferences, waist & hip ratio, systolic and diastolic blood pressure in between case and control. The value of Systolic blood pressure was 126 ± 15.84 mmHg in diabetes and 117 ± 15.46 mmHg in the control group, whereas the diastolic blood pressure was 82 ± 8.12 mmHg and 79 ± 8.89 mmHg, respectively. There were significant differences found in the waist and hip circumference in T2DM & controls, which were in (94.68±8.64) cm, (103.23±7.75) cm & (87.75±10.67) cm, (97.52±9.34) cm respectively.There were significant increases in mean VAI in T2DM compared to control, where p <0.001 & it was 3.93±2.72 in the case and 2.60±2.22 in control respectively. LSD test within One-way ANOVAhad done to test the differences of fast food taking habit pattern per week with different glycemic, Lipidemic markers and had shown significant difference with fasting blood glucose, 2 hours after breakfast, HBA1c with fast food taking group where p values were 0.01, 0.004, 0.03 respectively and non -significantly associated with HOMA-IR, HOMAB%, VAI, TAG, Cholesterol & LDL-C level in the study population. Multiple linear regression of VAI with glycemic and Lipidemic parameters and significant (p<0.001) association was found for HBA1c and HDL-C in the study population. Correlation of VAI with anthropometric, glycemic and Lipidemic parameters shows a significant (p <0.001) positive correlation with FBS, ABF, HBA1C, TAG, Cholesterol, LDL-C, HOMAIR and negative correlation with HDLC in T2DM subjects. Conclusion: VAI was positive and significantly correlated with FBS, ABF, HBA1c, TAG, Cholesterol, LDL-C, HOMA-IR and negatively correlated with HDL-C. VAI was non-significantly associated with fast food taking habit in the study population.
Keywords: Visceral adiposity index, Dietary patterns, Fast food taking habit, Type-2 Diabetes Mellitus, HBA1C, Fasting blood sugar,HOMA-IR..