Role of Lifestyle Changes in the Management of Chronic Liver Disease

Metabolic and Autoimmunity Liver Unit, Bambino Gesù Children's Hospital and Research Institute, S, Onofrio Square, 4, 00165 Rome, Italy.
BMC Medicine (Impact Factor: 7.25). 06/2011; 9(1):70. DOI: 10.1186/1741-7015-9-70
Source: PubMed


The prevalence of obesity worldwide has dramatically increased during the last three decades. With obesity comes a variety of adverse health outcomes which are grouped under the umbrella of metabolic syndrome. The liver in particular seems to be significantly impacted by fat deposition in the presence of obesity. In this article we discuss several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status. The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity. Here we summarize the current evidence supporting non-pharmacological, lifestyle interventions that lead to weight reduction, improved physical activity and better nutrition as part of the management and treatment of these liver conditions.

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Available from: Valerio Nobili, Jul 29, 2014
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    • "Liver disorders are among the most serious sicknesses in the population. Together with healthy lifestyle recommendation, therapies for hepatic diseases are necessary and need be more effective and economical [80]. Botanical medicines have been used traditionally worldwide for the prevention and treatment of liver disease. "
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    • "Regular aerobic exercise has been suggested as an appropriate means for the activation of antioxidant and immunological defenses, reduction of inflammatory processes, and improvement in quality of life, mainly in metabolic syndrome diseases (Kuo et al. 2007; Kelley et al. 2011). Also, the exercise combined with healthy eating, including low fat intake, is highly efficacious for improving serum lipid profiles, quality-of-life , and complications of obesity, metabolic syndrome, and NASH (Zivkovic et al. 2007; Nobili et al. 2011). In chemically induced rodent carcinogenesis models, moderate exercise (running and swimming) reduces the development of preneoplastic and neoplastic lesions in the colon and mammary gland (Hoffman-Goetz 2003; Na and Oliynyk 2011). "
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    • "Obesity and the associated metabolic complications are increasingly recognized as independent risk factors for diminished response to therapy and more severe liver disease [14]. Several types of hepatic conditions such as non-alcoholic fatty liver disease and chronic infection with hepatitis C virus are worsened by the presence of obesity in patients [15] [16]. "

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