ChemInform Abstract: Chiral Broensted Acid-Catalyzed Asymmetric Trisubstituted Aziridine Synthesis Using α-Diazoacyl Oxazolidinones.

ArticleinJournal of the American Chemical Society 133(25):9730-3 · June 2011with10 Reads
Impact Factor: 12.11 · DOI: 10.1021/ja203901h · Source: PubMed


    Despite the remarkable advances in catalytic asymmetric aziridinations over the past decades, establishing a general procedure for the stereoselective synthesis of trisubstituted aziridines has remained an elusive goal. Chiral N-triflyl phosphoramide-catalyzed reactions of N-α-diazoacyl oxazolidinones and N-Boc imines were developed as a solution to this unmet challenge.