Abstract Background: The research presented in this article has satisfactorily followed the earlier protocols of the last 2 authors and has successfully replicated their earlier work, which utilized an intention-host device to increase the pH of highly purified water in equilibrium with air by approximately +1 pH units at room temperature with no intentional chemical additions. Methods: In addition, the present experimental research, by the first 2 authors, breaks important new ground by revealing examples of both (1) different time-dependent pH-profiles than found in the earlier work and (2) a very nontraditional order of chemical-like reaction kinetics than has heretofore been observed. Conclusions: The time-dependence behavior of these reaction sequences support the hypothesis that such intention-host devices can produce a significant measure of coupling between two uniquely different, and normally noninteracting, levels of physical reality that exhibit a reciprocal-type of substance behavior.