Fermented Milk Containing Bifidobacterium lactis DN-173 010 in Childhood Constipation: A Randomized, Double-Blind, Controlled Trial

Department of Paediatric Gastroenterology and Nutrition, Emma's Children's Hospital Academic Medical Centre, Amsterdam, The Netherlands.
PEDIATRICS (Impact Factor: 5.47). 06/2011; 127(6):e1392-9. DOI: 10.1542/peds.2010-2590
Source: PubMed


Constipation is a frustrating symptom affecting 3% of children worldwide. A fermented dairy product containing Bifidobacterium lactis strain DN-173 010 was effective in increasing stool frequency in constipated women. Our aim was to assess the effects of this product in constipated children.
In this prospective randomized, double-blind, controlled trial, 159 constipated children (defecation frequency < 3 times per week) were randomly allocated to receive either a fermented dairy product that contains B lactis DN-173 010 (n = 79) or a control product (n = 80) twice a day for 3 weeks. The primary endpoint was the change in stool frequency from baseline to after 3 weeks of product consumption. Analyses were by intention to treat.
Eleven children did not return to any follow-up visit (5 in the probiotic group, 6 in the control group) and were therefore excluded from the final analysis. Thus, 74 children in each group were analyzed. The change in stool frequency from baseline to after 3 weeks of product consumption increased in both groups, but the difference was not statistically significant (2.9 ± 3.2 in probiotic group versus 2.6 ± 2.6 in control group, P = .35). There were no serious adverse events.
In constipated children, the fermented dairy product containing B lactis strain DN-173 010 did increase stool frequency, but this increase was comparable in the control group. There is currently not sufficient evidence to recommend fermented dairy products containing B lactis strain DN-173 010 in this category of patients. Future studies should focus on whether a longer period of probiotic products is more effective in children who have a short history of constipation.

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Available from: Marijke Roseboom, Jan 18, 2016
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    • "Bu et al. [17], showed that the use of Lactobacillus rhamnosus Lce35 increased evacuation frequency, however, there was no difference when compared to children who took oral laxatives. Two other studies [18,19] showed no evidence of improvement with constipated children using probiotics. "
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    • "Different categories of food have been studied for addition of probiotic strains, from widely used dairy products to other foods that may be less used or not yet appreciated (Martins et al., 2013). Fermented milk containing well-known probiotic strains has been used to relieve constipation in women and children, improving defecation frequency as well as stool condition and consistency (Tabbers et al., 2011; Yang et al., 2008). A recent review on probiotics and bowel habits indicated that short-term probiotic supplementation decreased intestinal transit time with consistently greater effects in constipated adults (Miller & Ouwehand, 2013). "
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    Full-text · Article · Jul 2014 · International Journal of Food Sciences and Nutrition
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    • "Lcr35 8 9 108 CFU/day (250 mg/two capsules/b.i.d./4 weeks) 0.25 (0.1–0.61) Significant improvement with probiotic over placebo Tabbers et al. 2011 17 B. lactis DN-173 010 "
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