The Finnish Diabetes Risk Score (FINDRISC) as a screening tool for hepatic steatosis

Preventive Medicine Center Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Annals of Medicine (Impact Factor: 3.89). 05/2011; 43(6):487-94. DOI: 10.3109/07853890.2011.554428
Source: PubMed


INTRODUCTION. Hepatic steatosis due to non-alcoholic fatty liver disease is associated with obesity, dyslipidemia, insulin resistance, and type 2 diabetes. The Finnish Diabetes Risk Score (FINDRISC) is a prognostic screening tool to detect people at risk for type 2 diabetes without the use of any blood test. The objective of this study was to evaluate whether FINDRISC can also be used to screen for the presence of hepatic steatosis. PATIENTS AND METHODS. Steatosis was determined by ultrasound. The study sample consisted of 821 non-diabetic subjects without previous hepatic disease; 81% were men (mean age 45 ± 9 years) and 19% women (mean age 41 ± 10 years). RESULTS. Steatosis was present in 44% of men and 10% of women. The odds ratio for one unit increase in the FINDRISC associated with the risk of steatosis was 1.30 (95% CI 1.25-1.35), similar for men and women. The area under the receiver operating characteristics curve for steatosis was 0.80 (95% CI 0.77-0.83); 0.80 in men (95% CI 0.77-0.83) and 0.83 (95% CI 0.73-0.93) in women. CONCLUSIONS. Our data suggest that the FINDRISC could be a useful primary screening tool for the presence of steatosis.

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    • "some of the dysmetabolic changes detected in this scenario may also occur in alcoholic fatty liver disease, e. g. hypertriglyceridemia, other characteristics of the atherogenic dyslipidemia are more prevalent in individuals with NAFLD.[2]HS one of the components of NAFLD, is strongly associated with other makers of increased cardiovascular risk such as systemic arterial hypertension[3], insulin resistance[4], low-grade inflammation[5], atherogenic dyslipidemia[6], and metabolic syndrome[7]. Mechanistic pathways underlying this association, however, are poorly understood. "
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    ABSTRACT: Aims: Nonalcoholic hepatic steatosis (HS) is associated with hypertension and increased cardiovascular risk. While Blood pressure hyper reactive response (HRR) during peak exercise indicates an increased risk of incident hypertension and increased cardiovascular risk, no data on the association of nonalcoholic HS and HRR exists. In this study, we have evaluated the association of HS with HRR. Methods: We included 13,410 consecutive individuals with a mean age: 42.4±8.9 years, 3,561 (26.6%) female with normal resting blood pressure and without a previous diagnosis of hypertension, who underwent symptom limited exercise treadmill test, abdominal ultrasonography and clinical and laboratory evaluation. HS was detected by abdominal ultrasonography. HRR was defined by a peak exercise systolic blood pressure > 220 mmHg and/or elevation of 15 mmHg or more in diastolic blood pressure from rest to peak exercise. Results: The prevalence of HS was 29.5% (n=3,956). Overall, 4.6% (n=619) of the study population presented a HRR. Subjects with HS had a higher prevalence of HRR (8.1% vs. 3.1%, odds ratio 2.8, 95% CI 2.4 - 3.3, p<0.001). After adjustment for body mass index, waist circumference, fasting plasma glucose and LDL-cholesterol, HS (odds ratio 1.4, 95% CI 1.1 - 1.6, p=0.002) remained independently associated with HRR. HS was additive to obesity markers in predicting exercise HRR. Conclusions: Nonalcoholic HS is independently associated with hyper reactive exercise blood pressure response.
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    • "Several previous studies have shown that FINDRISC was related to type 2 diabetes, the metabolic syndrome, insulin resistance [6], [24], [25]. In a recent cross-sectional study including 821 Brazil non-diabetic subjects without previous hepatic disease, it was found that the FINDRISC could be a useful primary screening tool for the presence of steatosis [5]. In that study the ROC curve for the undiagnosed prevalent diabetes was 0.80, 0.80 in men and 0.83 in women, which was consistent with the present findings. "
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    ABSTRACT: Hepatic steatosis has been related to insulin resistance and increased diabetes risk. We assessed whether combination of diabetes risk factors, evaluated by the Finnish Diabetes Risk Score, was associated with risk of hepatic steatosis in an apparently healthy Chinese population. The study samples were from a community-based health examination survey in central China. In total 1,780 men and women (18-64 y) were included in the final analyses. Hepatic steatosis was diagnosed by ultrasonography. We created combination of diabetes risk factors score on basis of age, Body Mass Index, waist circumference, physical activity at least 4 h a week, daily consumption of fruits, berries or vegetables, history of antihypertensive drug treatment, history of high blood glucose. The total risk score is a simple sum of the individual weights, and values range from 0 to 20. Hepatic steatosis was present 18% in the total population. In multivariate models, the odds ratios of hepatic steatosis were 1.20 (95%CI 1.15-1.25) in men and 1.25 (95%CI 1.14-1.37) in women by each unit increase in the combination of diabetes risk factors score, after adjustment for blood pressure, liver enzymes, plasma lipids, and fasting glucose. The area under the receiver operating characteristic curve for hepatic steatosis was 0.78 (95%CI 0.76-0.80), 0.76 in men (95%CI 0.74-0.78) and 0.83 (95%CI 0.79-0.87) in women. Our data suggest that combination of major diabetes risk factors was significantly related to risk of hepatic steatosis in Chinese adults.
    Full-text · Article · Mar 2014 · PLoS ONE

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