Notch Signaling: A Role in Sleep and Stress

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.
Current biology: CB (Impact Factor: 9.57). 05/2011; 21(10):R397-8. DOI: 10.1016/j.cub.2011.04.014
Source: PubMed


The molecular pathways regulating sleep remain poorly understood. Studies in this issue demonstrate a role for Notch signaling in sleep regulation as well as stress response in both Caenorhabditis elegans and Drosophila.

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    • "Insects are known to go through rest phases that resemble key features of sleep [Drosophila (Hendricks et al., 2000; Shaw et al., 2000); honeybee (Kaiser, 1988)]. In Drosophila, the genes and signaling cascades that control sleep are already well understood (Sehgal and Mignot, 2011), and some of these regulatory systems can be related to synaptic plasticity and memory consolidation (Foltenyi et al., 2007; Bushey et al., 2011; Seugnet et al., 2011; Wu and Raizen, 2011). The neural networks involved in these cellular processes highlight the role of the mushroom body (Joiner et al., 2006; Guo et al., 2011) and an identified protocerebral cell group, the octopamine-containing neurons in the pars intercerebralis (Crocker et al., 2010), possibly also involved in synaptic plasticity and memory consolidation. "
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