Restless Legs Syndrome in Multiple Sclerosis

Department of Neurology, Tokat, Turkey.
European Neurology (Impact Factor: 1.36). 05/2011; 65(5):302-6. DOI: 10.1159/000327315
Source: PubMed


Multiple sclerosis (MS) is a demyelinating neurodegenerative inflammatory autoimmune disease. Restless legs syndrome (RLS) is characterized as a strong urge to move the legs to stop abnormal sensations there. In this study, we aimed to investigate whether or not the increased RLS frequency seen in MS could be associated with depression and fatigue.
The study involved 98 patients with definite MS and 129 healthy volunteers. The Beck Depression Inventory and Fatigue Severity Scale were used to assess all participants. The patients and the healthy volunteers were examined for RLS according to the criteria of the International Restless Legs Syndrome Study Group.
When the factors related to RLS in MS were evaluated, there were significant relationships found among age, type of MS, pyramidal symptoms, intestinal and bladder symptoms, number of lesions in MR, depression, and fatigue. Risk factors for RLS were also seen more frequently in the MS group than in the healthy volunteers.
RLS was seen 2.55 times more frequently in patients with MS than in the control group. This was due to the existence of numerous factors rather than a single factor - including depression and fatigue.

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Available from: Unal Erkorkmaz, Mar 11, 2014
    • "We determined that the difference in severity of RLS between our MS group and controls was statistically significant (the severity was greater in control group). This is in contrast with a lot of studies that found that severity of RLS was greater than in the MS group.[10] Our hypothesis is that MS patients have other complaints like spasticity and weakness in their lower limbs, so may be their complaint of RLS severity is less than in the normal subjects. "
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