Primary carcinoid tumour in horseshoe kidney

Department of Pathomorphology, Collegium Medicum, Jagiellonian University.
Polish journal of pathology: official journal of the Polish Society of Pathologists (Impact Factor: 1.13). 01/2011; 62(1):72-4.
Source: PubMed


Primary renal carcinoid tumours are extremely rare. To date, approximately 60 cases have been reported, mostly as case reports with only few series noted. The pathogenesis of this tumour is uncertain because neuroendocrine cells are not found in normal adult renal parenchyma. We report a case of primary renal carcinoid occurring in a horseshoe kidney in a 66-year-old patient. A clinical, histological and immunohistochemical picture of this tumour is presented.

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Available from: Radosław Litwinowicz, May 21, 2015
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    • "The diagnosis of primary carcinoid tumour of the kidney has been reported to be incidental in 25–30% of cases [50]. This is similar to the findings of this review with primary carcinoid tumour of the kidney diagnosed as an incidental finding in 28.6% of cases [13, 18, 20, 23, 32]. The clinical presentation is similar to other renal neoplasms. "
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    ABSTRACT: Context. Primary renal carcinoid tumours are rare. Their pathogenesis is unknown and the clinical presentation is similar to other renal tumours thus posing diagnostic dilemmas for clinicians. Objectives. To review the literature for case reports of primary renal carcinoids. Methods. Literature was extensively searched for case reports for primary renal carcinoids. Reports of metastatic carcinoids to the kidneys were excluded. Results. Approximately less than 90 cases of primary carcinoid tumours of the kidney have been reported in the literature. A total of 29 cases of primary renal carcinoids were reviewed. The mean age of presentation was 48 years (range 29-75) with both right kidney (48.3%) and left kidney (44.8%) being equally affected. 28.6% of the cases reviewed were diagnosed as an incidental finding. The mean followup time was 20 months with 73.1% of patients without evidence of disease after surgical treatment (radical or partial nephrectomy). Primary carcinoid tumours of the kidney are often well differentiated tumours. They are often misdiagnosed because of their rarity and similar presentation with other renal tumours. Conclusions. Primary carcinoid tumours of the kidney are rare tumours with an indolent course with frequent metastasis. Metastatic work up and followup is required in their management.
    Full-text · Article · Aug 2013 · Advances in Urology
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    ABSTRACT: Primary carcinoid tumors of the kidney are very rare, malignant tumors consisting of neuroendocrine cells. The pathogenesis of renal carcinoid is unclear because neuroendocrine cells are not normally found in adult renal parenchyma. Electron microscopy, immunohistochemistry, octreotide scan, positron emission tomography along with conventional radiographic imaging techniques are used in diagnosis and follow-up. Presenting symptoms usually include flank pain and haematuria. Early stage disease is treated with surgery only. However, randomized trials are lacking because of the very low number of reported cases. Thus, the role of debulking surgery, chemotherapy, radiotherapy, octreotide and targeted therapy in the management of advanced disease remains an open question. In this article the clinicopathologic features and prognosis of this very rare disease along with treatment outcomes of the reported cases are reviewed. In addition, we report a new case of a metastatic primary renal atypical carcinoid tumor treated with octreotide therapy.
    Full-text · Article · Mar 2013 · Critical reviews in oncology/hematology
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    ABSTRACT: Primary renal carcinoid tumors are extremely rare kidney lesions, with fewer than 100 reported cases previously. We describe a 75-year-old man with an incidentally detected cystic renal mass. Computed tomography showed a 3 cm tumor with a cystic component enhanced with contrast. No evidence of metastasis was detected. We treated the patient with radical nephrectomy. Pathological examinations revealed a cellular arrangement specific to carcinoid tumor and positive for chromogranin A, neural cell adhesion molecule, and somatostatin receptor type 2. The tumor cells had a mitotic count of 4 mitoses/10 high-power fields, and the level of the proliferation marker Ki-67 was 5%. The pathological diagnosis was renal neuroendocrine tumor grade 2. No local recurrence and no systemic metastasis were detected during the 18-month follow-up period. To our knowledge, this is the 6th case of renal neuroendocrine grade 2 tumor reported thus far.
    Full-text · Article · Jan 2015
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