A case of prostatic adenocarcinoma with Paneth cell-like appearance
Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.Polish journal of pathology: official journal of the Polish Society of Pathologists (Impact Factor: 1.13). 01/2011; 62(1):60-4.
Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immunohistochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
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