Discovering Molecular Targets in Cancer With Multiscale Modeling

Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Drug Development Research (Impact Factor: 0.77). 02/2011; 72(1):45-52. DOI: 10.1002/ddr.20401
Source: PubMed


Multiscale modeling is increasingly being recognized as a promising research area in computational cancer systems biology. Here, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross-scale analytical technique can be useful in identifying high-value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step towards systems medicine.

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Available from: Zhihui Wang, Jan 16, 2015
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