Eukaryotic Type Translation Initiation Factor 2: Structure-Functional Aspects

ArticleinBiochemistry (Moscow) 76(3):283-94 · March 2011with10 Reads
Impact Factor: 1.30 · DOI: 10.1134/S0006297911030011 · Source: PubMed


    Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.