ChemInform Abstract: Gram Scale Synthesis of 3-Fluoro-1-hydroxyacetone Phosphate: A Novel Donor Substrate in Rabbit Muscle Aldolase-Catalyzed Aldol Reactions.

ArticleinChemical Communications 47(23):6647-9 · June 2011with11 Reads
Impact Factor: 6.83 · DOI: 10.1039/c1cc11579k · Source: PubMed


    An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR.