Exercise, Brain, and Cognition Across the Lifespan

Beckman Institute for Advanced Science and Technology, Dept. of Psychology, Univ. of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Journal of Applied Physiology (Impact Factor: 3.06). 04/2011; 111(5):1505-13. DOI: 10.1152/japplphysiol.00210.2011
Source: PubMed


This is a brief review of current evidence for the relationships between physical activity and exercise and the brain and cognition throughout the life span in non-pathological populations. We focus on the effects of both aerobic and resistance training and provide a brief overview of potential neurobiological mechanisms derived from non-human animal models. Whereas research has focused primarily on the benefits of aerobic exercise in youth and young adult populations, there is growing evidence that both aerobic and resistance training are important for maintaining cognitive and brain health in old age. Finally, in these contexts, we point out gaps in the literature and future directions that will help advance the field of exercise neuroscience, including more studies that explicitly examine the effect of exercise type and intensity on cognition, the brain, and clinically significant outcomes. There is also a need for human neuroimaging studies to adopt a more unified multi-modal framework and for greater interaction between human and animal models of exercise effects on brain and cognition across the life span.

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Available from: Teresa Liu-Ambrose, Jun 26, 2015
    • "Indeed, this is consistent with the acute exercise literature in the general population that suggests that after a single bout of aerobic exercise, speed-related aspects of executive control might be improved. This too is inline with the exercise training literature in the general population that describes robust, beneficial effects of chronic aerobic exercise on executive function (Voss et al., 2011). The seemingly beneficial effects of acute exercise on cognition in MS complement the cross-sectional associations of fitness and cognition; this advances the field closer towards the development of an optimal exercise training intervention on cognitive processing speed and executive functioning in this population. "
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    ABSTRACT: Cognitive dysfunction is highly prevalent, disabling, and poorly-managed in persons with multiple sclerosis (MS). Exercise training represents a promising approach for managing this clinical symptom of the disease. However, results from early randomized controlled trials of exercise on cognition in MS are equivocal, perhaps due to methodological concerns. This underscores the importance of considering the well-established literature in the general population that documents robust, beneficial effects of exercise training on cognition across the lifespan. The development of such successful interventions is based on examinations of fitness, physical activity, and acute exercise effects on cognition. Applying such an evidence-based approach in MS serves as a way of better informing exercise training interventions for improving cognition in this population. To that end, this paper provides a focused, updated review on the evidence describing exercise effects on cognition in MS, and develops a rationale and framework for examining acute exercise on cognitive outcomes in this population. This will provide keen insight for better developing exercise interventions for managing cognitive impairment in MS.
    No preview · Article · Nov 2015 · Neuroscience & Biobehavioral Reviews
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    • "Physical activity promotes a wide array of neurological changes, including the enhancement of learning, memory, and executive L. Tomlinson et al. / Neuropharmacology xxx (2015) 1e15 2 Please cite this article in press as: Tomlinson, L., et al., Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity, Neuropharmacology (2015), function in both children and adults (Hopkins et al., 2012; Pereira et al., 2007; Voss et al., 2011). Many of these activity-related neurological changes have been primarily associated with changes in neurons (van Praag, 2009). "
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    ABSTRACT: Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences.
    Full-text · Article · Sep 2015 · Neuropharmacology
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    • "It is well accepted that motor recovery after stroke is achieved through cortical reorganization, in which the brain and central nervous system (CNS) adapt in response to environmental and behavioral change to acquire novel information by modifying neural connectivity and function (Knaepen, Goekint, Heyman, & Meeusen, 2010; Mang, Campbell, Ross, & Boyd, 2013). Although the exact mechanism for cortical reorganization is not known, neurotrophins are thought to play a major role by enabling neuronal survival, potentiation, and differentiation; promoting dendritic growth and remodeling; and promoting synaptic plasticity (Lin & Kuo, 2013; Voss, Nagamatsu, Liu-Ambrose, & Kramer, 2011). Brain-derived neurotrophic factor (BDNF) is of particular interest in basic science and rehabilitation research because of its responsiveness to physical activity and exercise (Knaepen et al., 2010). "
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    ABSTRACT: Previously, we demonstrated that forced aerobic exercise (FE) increases the pattern of neural activation in Parkinson's disease. We sought to evaluate whether FE, when coupled with repetitive task practice, could promote motor recovery poststroke. A 46-yr-old man with ischemic stroke exhibited chronic residual upper-extremity deficits, scoring 35/66 on the Fugl-Meyer Assessment (FMA) at baseline. He completed 24 training sessions comprising 45 min of FE on a motorized stationary bicycle followed by 45 min of upper-extremity repetitive task practice. From baseline to end of treatment, the FMA score improved by 20 points, perceived level of recovery on the Stroke Impact Scale increased by 20 percentage points, and cardiovascular function measured by peak oxygen uptake improved 30%. These improvements persisted 4 wk after the intervention ceased. FE may be a safe and feasible rehabilitation approach to augment recovery of motor and nonmotor function while improving aerobic fitness in people with chronic stroke. Copyright © 2015 by the American Occupational Therapy Association, Inc.
    Full-text · Article · Jul 2015
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