Article

Inhibition of peripheral blood neutrophil oxidative burst in periodontitis patients with a homeopathic medication Traumeel S

STOMATOLOGIJA Baltic Dental and Maxillofacial Journal, Kaunas, Lithuania.
Medical science monitor: international medical journal of experimental and clinical research (Impact Factor: 1.43). 05/2011; 17(5):CR284-91. DOI: 10.12659/MSM.881769
Source: PubMed

ABSTRACT

The anti-inflammatory effects of a homeopathic remedy, Traumeel S, have been observed in experimental and clinical studies; however, its antioxidant properties have not been elucidated. The aim of the present study was to evaluate the antioxidant effects of Traumeel S on peripheral blood neutrophils in patients with periodontitis.
The study was performed using venous blood of 22 individuals with chronic periodontitis and 21 healthy subjects. The antioxidant effects of Traumeel S on the production of reactive oxygen species by unstimulated and stimulated with unopsonized E. coli neutrophils were investigated using luminol- and lucigenin-dependent chemiluminescence (CL).
Polymorphonuclear leukocytes of periodontitis patients produced higher levels (p<0.01) of light output of lucigenin-dependent chemiluminescence and significantly reduced (p<0.01) light output of luminol-dependent chemiluminescence than analogous cells of healthy subjects. Highly diluted (10⁻⁴ of the stem solution) Traumeel S significantly (by approximately 50%) reduced superoxide-induced oxidation of lucigenin by unstimulated and stimulated with unopsonized E. coli polymorphonuclear leukocytes of periodontitis patients and had a tendency to intensify luminol-dependent chemiluminescence. Preincubation of the unstimulated and stimulated with unopsonized E. coli polymorphonuclear leukocytes of healthy subjects with Traumeel S exerts no inhibitory action on the luminol- and lucigenin-dependent chemiluminescence of the above-mentioned cells.
This study indicates that Traumeel S may significantly reduce production of superoxide anion by unstimulated and stimulated peripheral blood polymorphonuclear neutrophils of periodontitis patients.

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    • "Figure 4shows the putative components of the acute cell danger response and pathways to sickness or to healing. Like NPs, (a) homeopathic medicines can modulate reactive oxygen species278279280281, heat shock proteins[185,254,282], and cytokine release[187,192,198,199,266]and trigger biological signaling cascades in cancer cells[187,188]; and (b) nanoparticles constitute an emerging type of danger signal for cells[81]. Consequently, further systematic examination of the effects of low dose HMs and their constituent NPs on the cell danger response pathway network is likely to be productive[257,282]. "

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