The Seroprevalence Rate, Vaccination Rate and Seroconversion Rate of Hepatitis A in Central Region of Korea

ArticleinThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 57(3):166-72 · March 2011with65 Reads
DOI: 10.4166/2011.57.3.166 · Source: PubMed

Acute hepatitis A (HAV) is markedly increasing recently on. Some patients with acute hepatitis A show severe clinical course. The seroprevalence rate of IgG anti-HAV has been changing with the regions and the times. Vaccination and seroconversion rate of HAV are not well known. In this study, we aimed to study the difference of seroprevalence rate of IgG anti-HAV according to various clinical factors and to know the vaccination rate and seroconversion rate below 10 years old in the central region of South Korea including Cheonan city. Seven hundred seventy two subjects were included in the study from January to September 2009. We analyzed seroprevalence rate of IgG anti-HAV according to sex, age, region, and other viral markers. We interviewed the history of vaccination(1st, 2nd) and analyzed seroconversion rate according to vaccination time below 10 years old. The total seroprevalence rate of IgG anti-HAV was 65.3%. The seroprevalence rate of IgG anti-HAV rate in 2nd, 3rd, and 4th decade was very low (1.9%, 18.8%, 44.8%). The vaccination rate of children was about 50%. The seroconversion rate after 1st, and 2nd vaccination were 85%, 96%. Catch-up vaccination for teenagers and young adults is needed. Immunizing children with HAV vaccine as a routine schedule should be considered.

    • "We developed a questionnaire that included several factors such as low family income [8,9], low level of parental education [8,10], young age of parents [10], birth order of the child [11,12], and region [6]. "
    [Show abstract] [Hide abstract] ABSTRACT: This study was designed to identify factors associated with hepatitis A immunization status and seropositivity in Korean children. In-person interviews, reviewing their vaccination cards and testing hepatitis A antibody were conducted with 389 children aged 1-3 years and 544 children aged 6-8 years. In all age groups, earlier birth order was the only significant factor in children receiving either single or both doses of the vaccination. And completion of the second dose of vaccination was a prerequisite for increased seropositivity. Additionally, household income had a positive impact on seropositivity only in children aged 6-8 years. Our findings suggest that presence of an economic barrier is the underlying cause of the decreased hepatitis A vaccination services in Korea. Therefore, hepatitis A vaccine should be included in the essential National Immunization Program.
    Full-text · Article · Apr 2013
  • [Show abstract] [Hide abstract] ABSTRACT: Purpose: Although the overall incidence of hepatitis A in Korea has been decreasing recently, the adolescents born before the introduction of the hepatitis A vaccine remain to be highly vulnerable to outbreak. This study examines the unvaccinated adolescents' and their parents' knowledge and health beliefs toward hepatitis A vaccination. Methods: Healthy adolescents aged 13-19 years old who had no previous history of hepatitis A vaccine and hepatitis A infection, and their parents or legal guardians were the subjects of the study. The survey was conducted using a structured questionnaire based on the Health Belief Model, and examined the subjects' demographics, knowledge, and health beliefs (i.e., perceived susceptibility, severity, benefits, and barriers). Results: We included 157 adolescents and their parents/guardians (mean age: and years, respectively). The average knowledge item score for adolescents and parents was and (out of 18), respectively. Similarly, average Health Belief Model item scores were: susceptibility, and (range: 2-10); severity, and (range:5-25); benefits, and (range:5-25); and barriers, and (range:7-85). The major reason for not undergoing hepatitis A vaccination was lack of knowledge about its importance. Conclusions: Refresher health lectures about hepatitis A and the vaccine are needed by both the adolescents and their parents. Furthermore, the inclusion of hepatitis A vaccine in the national immunization program should be considered to reduce the risk of hepatitis A outbreak and to raise the vaccination coverage among the adolescents in Korea.
    Preview · Article · Jan 2013 · Korean Journal of Pediatric Infectious Diseases
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: Hepatitis A virus (HAV) is an important public health problem in Turkey. This study was aimed to determine the population-based seroprevalence of HAV in i̇zmir. Material and Method: In this cross-sectional study, a representative sample of the population, which was at the age of ≥15 years, was selected by using random stratification method. A total of 2156 healthy subjects participated in this present study. Blood specimens were collected for testing anti-HAV IgG, and were examined by using enzymelinked immunosorbent assay (ELISA). A questionnaire was also administered to obtain data regarding demographic characteristics and living conditions of the participants. Results: Anti-HAV IgG positivity was 93.9%. It was found that anti-HAV IgG seropositivity was higher in the subjects with lower income levels, lower education status, at older age, whereas it was lower in younger and single subjects. Conclusion: Improved water and food sanitation resulted in reduced seroprevalence of HAV at younger age groups in i̇zmir.
    No preview · Article · Sep 2013 · Nobel medicus
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