Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Bioscience Biotechnology and Biochemistry (Impact Factor: 1.06). 05/2011; 75(4):800-3. DOI: 10.1271/bbb.100918
Source: PubMed


Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

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