Study on the Meningoima Using FT-Mid-IR Spectroscopy
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.Guang pu xue yu guang pu fen xi = Guang pu (Impact Factor: 0.29). 02/2011; 31(2):353-6. DOI: 10.3964/j.issn.1000-0593(2011)02-0353-04
In the present investigation, 24 cases of meningoima tissues (including 12 cases of benign tumor and 12 cases of malignant tumor 12) were detected using FT-mid-IR spectroscopy linked with attenuated total reflectance (ATR) accessory. These FTIR spectra obtained from the above-mentioned meningoima tissues were analyzed and compared. Significant differences were found in the spectral features of different kinds of meningoima tissues for example fibrous type meningoima and endothelioid meningoima; and for the same type of meningoima tissues the significant differences in the spectram features can be also observed with the increase of grade malignancy. The malignant tumor can be distinguished primarily from benign tumor by the changes of position, shape and intensity of infrared absorption bands, particularly in the ranges of 1 000-1 500 cm(-1). The results show that the peak position of the bands (such as 1 160 cm(-1)) can be used to distinguish the characteristic of meningoima which are in agreement with the pathological results. The accuracy is larger than 85%. These results demonstrate that FT-mid-IR spectroscopy exhibits prospect to develop a novel, non-invasive and rapid method for the diagnosis the brain tumors.
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ABSTRACT: Nineteen cases of glioma tissues(including 10 cases of astrocytic tumors and 9 cases of oligoastrocytic tumors) were detected using FT-mid-IR spectroscopy linked with attenuated total reflectance(ATR) accessory. In the astrocytic tumors cases, there were 4 cases of pure astrocytic tumors(WHOI and II), 2 cases of anaplastic astrocytic tumors(WHO III) and 4 cases of glioblastoma(WHO IV). The FTIR spectra obtained from the brain tumor tissues were analyzed and compared. Significant differences were found in the peak position, band shape and intensity of infrared absorption spectra between the different grades of astrocytic tumors. The intensity of the band at ca. 1400 cm -1 band is increased with the malignancy grade of astrocytic tumors. In addition, some spectral differences between astrocytic tumors and oligoastrocytic tumors were observed. In the spectra of oligoastrocytic tumors, the peak position of 1240 and 1300 cm -1 shifted to low wavenumbers. And the band at ca. 1270 cm -1 appeared in the spectra of oligoastrocytic tumors which was not observed in the astrocytic tumors. These results demonstrate that FT-mid-IR spectroscopy exhibits prospect to develop a novel, non-invasive and rapid method for the detection of brain tumors.
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