Drinking water fluoridation and osteosarcoma incidence on the island of Ireland

National Cancer Registry, Ireland, Cork.
Cancer Causes and Control (Impact Factor: 2.74). 06/2011; 22(6):919-24. DOI: 10.1007/s10552-011-9765-0
Source: PubMed


The incidence of osteosarcoma in Northern Ireland was compared with that in the Republic of Ireland to establish if differences in incidence between the two regions could be related to their different drinking water fluoridation policies. Data from the Northern Ireland Cancer Registry (NICR) and the National Cancer Registry of Ireland (NCRI) on osteosarcoma incidence in the respective populations were used to estimate the age-standardised and age-specific incidence rates in areas with and without drinking water fluoridation. One hundred and eighty-three osteosarcoma cases were recorded on the island of Ireland between 1994 and 2006. No significant differences were observed between fluoridated and non-fluoridated areas in either age-specific or age-standardised incidence rates of osteosarcoma. The results of this study do not support the hypothesis that osteosarcoma incidence in the island of Ireland is significantly related to public water fluoridation. However, this conclusion must be qualified, in view of the relative rarity of the cancer and the correspondingly wide confidence intervals of the relative risk estimates.

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    • "One study investigated a second sample of cases drawn from the same source but found no association (including after assessment of bone F – levels in cases of osteosarcoma) (Kim et al. 2011). Largescale studies of all osteosarcomas recorded in Ireland from 1994–2006 (Comber et al. 2011) and throughout almost the entire continental USA from 1999–2006 (Levy & Leclerc 2012) found no association with F – exposure, regardless of sex or age. Another study considered all osteosarcomas and Ewing sarcomas diagnosed in Great Britain from 1980–2005 and once again, found no association (Blakey et al. 2014). "
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    ABSTRACT: This paper reviews and evaluates a number of claims recently made in the New Zealand scientific medical literature by opponents of community water fluoridation (CWF) about fluoride and fluoridation chemistry, as well as the dental and health effects of CWF. It is of concern that if these claims were considered appropriate evidence by health authorities or legislators, this may have a considerable negative impact upon the public's oral health.
    Preview · Article · Oct 2015 · Journal- Royal Society of New Zealand
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    • "The International Journal of Cancer Epidemiology, Detection, and Prevention were observed in incidence rates between fluoridated and nonfluoridated regions [16]. However, this study did not provide any statistical analysis for specific age groups under 25 years. "
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    ABSTRACT: It has been suggested that fluoride in drinking water may increase the risk of osteosarcoma in children and adolescents, although the evidence is inconclusive. We investigated the association between community water fluoridation (CWF) and osteosarcoma in childhood and adolescence in the continental U.S. We used the cumulative osteosarcoma incidence rate data from the CDC Wonder database for 1999-2006, categorized by age group, sex and states. States were categorized as low (≤30%) or high (≥85%) according to the percentage of the population receiving CWF between 1992 and 2006. Confidence intervals for the incidence rates were calculated using the Gamma distribution and the incidence rates were compared between groups using Poisson regression models. We found no sex-specific statistical differences in the national incidence rates in the younger groups (5-9, 10-14), although 15-19 males were at higher risk to osteosarcoma than females in the same age group (p<0.001). Sex and age group specific incidence rates were similar in both CWF state categories. The higher incidence rates among 15-19 year old males vs females was not associated with the state fluoridation status. We also compared sex and age specific osteosarcoma incidence rates cumulated from 1973 to 2007 from the SEER 9 Cancer Registries for single age groups from 5 to 19. There were no statistical differences between sexes for 5-14 year old children although incidence rates for single age groups for 15-19 year old males were significantly higher than for females. Our ecological analysis suggests that the water fluoridation status in the continental U.S. has no influence on osteosarcoma incidence rates during childhood and adolescence.
    Full-text · Article · Dec 2011
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    Full-text · Article · Aug 2011 · Journal of Epidemiology & Community Health
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