PTP4A3 (PRL-3) expression correlate with lymphatic metastases in gastric cancer

Department of General Pathomorphology, Medical University of Białystok, Białystok, Poland.
Folia Histochemica et Cytobiologica (Impact Factor: 1.36). 12/2010; 48(4):632-6. DOI: 10.2478/v10042-010-0070-7
Source: PubMed


Many studies have proved that protein tyrosine phosphatase type IVAmember 3 (PTP4A3, PRL-3) plays a major role in the metastasis of gastric cancer, especially to local lymph nodes. The objective of the current study was to assess the expression of PTP4A3 in gastric cancer in correlation with chosen anatomoclinical parameters and patients' survival. Atotal of 71 patients with gastric carcinomas were divided according to Lauren's, Goseki's, Bormann's and Kubo's classifications. The level of PTP4A3 was determined immunohistochemically using a mouse monoclonal anti-PTP4A3 antibody (clone 3B6, anti-human PTP4A3, Attogen Biomedical Research, USA). A statistically significant correlation was observed between PTP4A3 and Kubo's classifications (p=0.0454) and on the verge of statistical significance with Lauren's classification (p=0.0503). The expression of the protein was associated more with the poorly-differentiated mucoid carcinoma and diffused-type carcinoma (58% of cases). We demonstrated a statistically significant correlation between local lymph node involvement and positive expression of PTP4A3 in the primary tumour (p=0.0000). The current study seems to prove that PTP4A3 may have a significant impact on the lymphatic spread of gastric carcinoma. The protein expression is also significantly associated with gastric carcinomas having a worse prognosis, although patients' survival rate showed lack of correlation with PTP4A3 expression.

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Available from: Anna Pryczynicz, Oct 29, 2015
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    • "Afterwards, Wang et al. found that overexpression of PRL-3 was present in 47.7% of gastric carcinomas with the lymph node metastasis using monoclonal antibody [13] and reported its prognostic significance [13]. Although correlation between PRL-3 overexpression and lymph node metastasis or peritoneal metastasis has been reported at some aspects in gastric cancer [12,14], the identical expression in the primary tumors without metastasis, primary tumors with metastasis, and matched samples of primary lesion and liver metastasis has not been completely understood. Also, the prognostic value of PRL-3 expression has not been reached a consensus on its clinical significance. "
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    • "Increased levels of PRL-3 expression have previously been associated with the progression and metastasis of gastric and liver carcinomas [27] [29] [30] [31] [34] [35] [39]. The current report is the first to suggest that PRL-1 and PRL-2 may also play an important role in the development and/ or progression of these tumor types. "
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