Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma

Cardiothoracic Surgery, New York Hospital/Weill Cornell Medical Center, New York, NY, USA.
Lung cancer (Amsterdam, Netherlands) (Impact Factor: 3.96). 04/2011; 74(1):118-23. DOI: 10.1016/j.lungcan.2011.01.029
Source: PubMed


Characterization of the non-small cell lung cancer (NSCLC) genome has suggested that KRAS amplification is one of the commonest molecular abnormalities in NSCLC. However, the prevalence and clinicopathologic significance of KRAS amplification, and its relationship with KRAS activating mutations have not been well-defined. The purpose of this study was to establish the prevalence of KRAS amplification in two separate, large NSCLC cohorts, to define the clinicopathologic features of KRAS-amplified NSCLC in a single uniformly treated cohort, and to investigate the interplay between KRAS amplification and KRAS mutation.

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