Single dose oral mefenamic acid for acute postoperative pain in adults

Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Churchill Hospital, Oxford, Oxfordshire, UK, OX3 7LJ.
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 03/2011; 3(3):CD007553. DOI: 10.1002/14651858.CD007553.pub2
Source: PubMed


Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that is used as a painkiller (analgesic). Four studies involving a total of 842 participants were included in this review. Because fewer than 200 participants were treated with mefenamic acid within these four studies, results must be treated with caution. A good level of pain relief is experienced by almost half (48%) of those with moderate to severe postoperative pain after a single dose of mefenamic acid 500 mg, compared to about 20% with placebo, and fewer will need additional analgesia within 6 hours (47% versus 62%). This level of pain relief is comparable to that experienced with paracetamol 1000 mg. Adverse events could not be assessed in these studies.

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