A Rapidly Increasing Incidence of HIV and Syphilis Among Men Who Have Sex with Men in a Major City of China

Key Laboratory of Immunology for AIDS, Ministry of Health, the First Hospital, China Medical University, No.155,Nanjing North Street, Heping District, Shenyang, P.R.China, shenyang, Liaoning, China, 110001, 86-24-83282634, 86-24-83282634
AIDS research and human retroviruses (Impact Factor: 2.33). 03/2011; 27(11):1139-40. DOI: 10.1089/AID.2010.0356
Source: PubMed


The number of newly reported cases of HIV has significantly increased among men who have sex with men (MSM) in China over the past five years. Unfortunately, there have been few studies reporting incidence rates and related trends in MSM populations. This study addresses the lack of information on HIV incidence trends among MSM in Shenyang, Liaoning. Cross-sectional and prospective cohort studies implemented by our laboratory in 2006 found high prevalence and high incidence of HIV among MSM. . This study, a three-year prospective open cohort follow-up survey, examines trends in HIV prevalence and incidence of both HIV and syphilis infections among MSM in Shenyang, Liaoning.

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    • "The study was conducted in Shenyang, a capital city of Liaoning Province in northern China. The HIV epidemic has been rapidly increasing among MSM in Shenyang over the past 5–10 years; for example, the incidence rate was 4.7/100 person-years (PY) in 2007, 6.1/100 PY in 2008, and 10.2/100 PY in 2009 [21, 22]. "
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    ABSTRACT: Objective: To investigate the prevalence of recreational drug use and its relationship with HIV infection among Chinese MSM. Methods: A cross-sectional study of 625 MSM was conducted in Shenyang, China. Questionnaires were administered to collect information on recreational drug use and sexual behaviors. Blood specimens were collected to test for HIV and syphilis antibodies. Results: Nearly a quarter (23.2%, 145/625) of participants reported ever using recreational drugs, among which alkyl nitrites (poppers) was the most frequently used drug (19.2%), followed by methylmorphine phosphate (5.1%), methamphetamine (4.0%), and ketamine (0.8%). The overall prevalence of HIV and syphilis was 9.6% and 10.4%, respectively. Multivariate logistic analysis showed that recreational drug use was significantly correlated with age ≤ 25 year (adjusted odds ratio [aOR] = 1.6, 95% CI, 1.1-2.9), single marital status (aOR = 2.1, 95% CI, 1.2-3.6), and seeking male sexual partners mainly through Internet (aOR = 1.8, 95% CI, 1.8-2.8). Recreational drug use was independently associated with an increased risk of HIV infection (aOR = 3.5, 95% CI, 2.0-6.2). Conclusions: Our study suggests that recreational drug use is popular among Chinese MSM and is associated with significantly increased HIV infection risk. HIV prevention intervention programs should reduce both drug use and risky sexual behaviors in this population.
    Full-text · Article · Apr 2014
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    • "In 2008, one large scale cross-sectional study of MSM in 61 cities of China found that the average HIV prevalence had reached 4.9% [2]. Some metropolises such as Beijing [3], Shenyang [4], Harbin [5], Chongqing [6], and Zhengzhou [1]have all seen a rapidly increasing HIV prevalence among their MSM populations. "
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    ABSTRACT: Background Yunnan has the largest number of reported HIV/AIDS cases among all Chinese provinces, the reported prevalence of HIV among Yunnan men who have sex with men (MSM) passed 10%, while HIV incidence epidemic and molecular characteristics of new infected Yunnan MSM were not evaluated before. Methods An 18 months prospective followed up with a frequency of 3 month per visit were conducted among HIV seronegative MSM in Kunming cityduring 2009–2011. Interviewer-administrated questionnaires were carried out. Blood specimens were obtained to test for syphilis and HIV, in which HIV were evaluated by standard HIV enzyme immunoassay (EIA) and HIV nucleic acid amplification testing (NAAT). Near full-length regions of the HIV-1 were evaluated for subtyping, primary drug resistance mutations. Results During the follow-up 70.1% of the recruited 378 MSM retained in the cohort. Eleven MSM seroconverted to HIV and fifteen MSM seroconverted to syphilis. The HIV incidence and syphilis incidence was 3.5 (95% CI 1.8-6.2) cases /100 person year(PY) and 5.3 (95% CI 3.0-8.7) cases/100 PY, respectively. Multivariate analysis showed that baseline syphilis infection (aHR, 17.7), occupation (students vs. others [aHR, 5.7], retirees vs. others [aHR, 4.1]), bleeding experience after receptive anal intercourse (aHR,7.6), and minority ethnic(vs. Han) [aHR, 5.7] were independent risk factors for HIV seroconversion(each P<0.05). Among the 7/11 successfully amplified near full-length sequences, 71.4% (5/7) were CRF01_AE, and 28.6% (2/7) were CRF07_BC. Two HIV transmission pairs were detected among seroconverted minority ethnic MSM. Conclusions HIV incidence was moderately high among Yunnan MSM. Yunnan province need to strengthen both HIV and syphilis screening among MSM population. Some subpopulations of MSM, such as students, retirees and minority ethnic groups require more HIV epidemic surveillance and strengthened behavior interventions. HIV subtypes and primary drug resistance should be continually monitored to track cross-group transmission of HIV strains.
    Full-text · Article · Jan 2013 · BMC Infectious Diseases
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    ABSTRACT: China has experienced an increasing epidemic of sexually transmitted infections (STIs), including HIV. High risk groups likely to be infected include female sex workers (FSWs) and their clients, men who have sex with men (MSM), drug users and migrant workers. Prevention can be achieved through education of the population, condom promotion, early detection of symptomatic and asymptomatic people, and effective diagnosis and treatment of these patients and their partners. This article aims to describe the profile of the epidemic in high-risk groups in China as well as to detail the contributing factors and the implications for control. Programmes for the control of STIs should be immediate priorities in China, and primary and secondary prevention strategies are vital to this process.
    Full-text · Article · Oct 2011 · BMC Medicine
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