Lack of effect of a moderate hypocaloric diet on visfatin levels in morbid obese patients: Relationship with insulin resistance

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
European review for medical and pharmacological sciences (Impact Factor: 1.21). 12/2010; 14(12):1031-6.
Source: PubMed


The insulin-mimetic adipocytokine visfatin has been related to obesity. The aim of this study was to examine whether weight loss could change visfatin concentrations in morbidly obese patients and its relationship with insulin resistance.
This was an interventional study analyzing a population of 41 morbidly obese patients. A biochemical analysis was realized before and after 2 months on a hypocaloric diet.
After weight loss (average 4.41%), BMI, weight, fat mass, fat free mass, waist circumference, systolic blood pressure, serum glucose, total cholesterol, insulin and HOMA decreased. The serum concentrations of visfatin did not decrease (43.5 + 30.8 vs. 47.1 + 38.1 ng/ml). In the multivariate analysis visfatin concentrations as a dependent variable, only C reactive protein remained as an independent predictor in the model before diet, with an increase of 1.82 ng/ml (CI 95%: 0.02 - 3.61) basal visfatin concentrations with each increase of 1 mg/dl of CRP. Only HOMA remained as an independent predictor in the model after diet, with an increase of 11.4 ng/ml (CI 95%: 1.76 - 21.11) posttreatment visfatin concentrations with each increase of 1 unit HOMA.
Weight reduction after a 2 months on a hypocaloric diet is not associated with a significant change in circulating visfatin in morbidly obese patients.

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Available from: Daniel de Luis, Jan 07, 2015
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    • "Sonoli et al [7] found that visfatin had antiapoptotic activity and had a regulatory role in inflammation. Plasma levels of visfatin increased with the increase of C-reactive protein (CRP) levels, further suggesting visfatin's inflammatory effects [8] . Relevant research indicated that these inflammatory effects increased the risk of cardiovascular events in patients with obesity. "
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