Changes in murine hair with dietary selenium excess or deficiency

Department of Dermatology, Pusan Paik Hospital, College of Medicine, Inje University, Busan, Korea Department of Dermatology, Gospel Hospital, College of Medicine, Kosin University, Busan, Korea Sung Wook Park's Dermatology Clinic, Busan, Korea Department of Anatomy, College of Medicine, Inje University, Busan, Korea.
Experimental Dermatology (Impact Factor: 3.76). 03/2011; 20(4):367-9. DOI: 10.1111/j.1600-0625.2010.01207.x
Source: PubMed


It is known that an excess or deficiency of selenium (Se) causes abnormalities in hair. We evaluated changes in the hair follicles associated with Se imbalance in a C57BL/6 mouse model to better understand the role of Se in hair growth. Fifteen C57BL/6 mice were assigned to diets providing excessive, adequate, or deficient amounts of Se. Alopecia with poliosis was observed in the groups receiving either excessive or deficient selenium. Skin biopsy from alopecia patches showed increased telogen hair follicles with epidermal atrophy. There was a significant decrease of anti-apoptotic Bcl-2 and an increase of pro-apoptotic Bax in the excessive-Se group compared with the adequate group. We suggest that alopecia with poliosis is caused by changes in the hair follicle cycle due to the imbalance of Se and partially influenced by the decrease of the ratio of Bcl-2/Bax, which is associated with induction of apoptosis of keratinocytes.

Download full-text


Available from: Kee Suck Suh, Jan 21, 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The distribution of sialic acids and antimicrobial products (lysozyme, IgA, lactoferrin, β-defensin 2) as well as Rab3D in the eccrine glands of porcine snout skin was studied by sialoglycoconjugate histochemistry and immunohistochemistry. The secretory epithelium consisted of two types of secretory cells: dark and clear cells. The dark cells exhibited considerable amounts of sialoglycoconjugates, which included O-acetylated sialic acids, whereas sialic acids in the sequence Siaα2-3Gal1-4GlcNAc were confined to some of the dark cells. All antimicrobial substances and Rab3D were demonstrated to be also mainly present in some of the dark cells. Additionally, in the cytological and cytochemical features, the different characteristics were observed among the dark cells. The results obtained are discussed with regard to the functional significance of the eccrine glands. The secretory products elaborated by this gland type may function as protective agents in order to preserve the skin integrity of the snout region, considering that sialic acids and antimicrobial substances are important in general defense mechanisms.
    Full-text · Article · Jan 2012 · European journal of histochemistry: EJH
  • [Show abstract] [Hide abstract]
    ABSTRACT: The diagnosis of alopecia and other hair-related disorders can be challenging. An appreciation of the newest diagnostic techniques and newly described entities can help clinicians to provide the best care for patients. This article focuses on advances in the histologic evaluation of alopecia. Also discussed are recent advances in the understanding of hair-related disorders that do not result in alopecia. Advances in the understanding of disease mechanisms can help in treating hair disorders that proved refractory in the past.
    No preview · Article · Oct 2012 · Dermatologic clinics