Overview of treatment options for invasive fungal infections

Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC 27506, USA.
Medical mycology: official publication of the International Society for Human and Animal Mycology (Impact Factor: 2.34). 03/2011; 49(6):561-80. DOI: 10.3109/13693786.2011.560197
Source: PubMed


The introduction of several new antifungals has significantly expanded both prophylaxis and treatment options for invasive fungal infections (IFIs). Relative to amphotericin B deoxycholate, lipid-based formulations of amphotericin B have significantly reduced the incidence of nephrotoxicity, but at a significant increase in drug acquisition cost. Newer, broad-spectrum triazoles (notably voriconazole and posaconazole) have added significantly to both the prevention and treatment of IFIs, most notably Aspergillus spp. (with voriconazole) and the treatment of some emerging fungal pathogens. Finally, a new class of parenteral antifungals, the echinocandins, is employed most frequently against invasive candidal infections. While the role of these newer agents continues to evolve, this review summarizes the activity, safety and clinical applications of agents most commonly employed in the treatment of IFIs.

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Available from: Mary L. Townsend, Oct 27, 2014
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    • "Invasive aspergillosis is associated with a high rate of morbidity and mortality (as high as 50%) in these patients (Nivoix et al., 2008). However, there are limited effective antifungal drugs available to treat invasive apergillosis (see Pound et al., 2011 for a review). Though amphotericin B has been used with some success, it has been associated with high nephrotoxicity. "
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