A novel and stable non-enzymatic glucose sensor was developed based on the chemical reduction of Cu(2)O nanoparticles on Carbon Vulcan XC-72 using NaBH(4) as the reducing agent via the impregnation method. Different molar ratios of NaBH(4) to the copper salt were employed during the reduction step. This was found to affect the morphology; composition and structure of the prepared samples as investigated by TEM, EDX and XRD analyses. Cyclic voltammetry and chronoamperometry were applied to examine the electrocatalytic activity of the different samples of Cu(2)O/Carbon Vulcan XC-72 towards glucose oxidation in alkaline medium. The 'x70' sample got the highest oxidation current density and the lowest oxidation potential. The performance of this sensor was evaluated showing a wide linear range up to 6mM with sensitivity of 629 μA cm(-2)mM(-1) and detection limit of 2.4 μM. Its good tolerance to ascorbic acid with long-term stability elects Cu(2)O/Carbon Vulcan XC-72 as a promising glucose sensor.
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"Glucose oxidase (GO x ) has been widely used to construct various amperometric biosensors for glucose detection due to its high sensitivity and selectivity to glucose . However, GO x -based biosensors suffer from problems because of the disadvantages of the enzyme-modified electrodes , such as instability, high cost, complicated immobilization process, the requirement of low temperature storage, and their PH and toxic environment    . To resolve this problem, many attempts have been made to develop nonenzymatic glucose sensors in recent years. "
[Show abstract][Hide abstract] ABSTRACT: Copper oxide (CuO) films directly grown on Ti substrate have been successfully prepared via a hydrothermal method and used to construct an amperometric nonenzymatic glucose sensor. XRD and SEM were used to characterize the samples. The electrochemical performances of the electrode for detection of glucose were investigated by cyclic voltammetry and chronoamperometry. The CuO films based glucose sensors exhibit enhanced electrocatalytic properties which show very high sensitivity (726.9 μA mM−1 cm−2), low detection limit (2 μM), and fast response (2 s). In addition, reproducibility and long-term stability have been observed. Low cost, convenience, and biocompatibility make the CuO films directly grown on Ti substrate electrodes a promising platform for amperometric nonenzymatic glucose sensor.
Full-text · Article · Jun 2014 · Journal of Nanomaterials
[Show abstract][Hide abstract] ABSTRACT: Nano PtCuO particles were deposited on Vulcan XC-72R carbon black using the impregnation and microwave irradiation methods. The prepared catalysts were characterized by XRD, TEM and EDX analyses. TEM images indicated that the microwave method provides homogeneously distributed catalyst particles in smaller size, compared to the one prepared by the impregnation method. The electrocatalytic activity of Pt-CuO/C electrocatalysts was investigated to oxidize methanol in 0.5 M H2SO4 solution by applying cyclic voltammetry and chronoamperometry techniques. The oxidation current density of Pt-CuO/C electrocatalyst, prepared by the microwave method, showed two folds increment with a potential shift in the negative direction by 69 and 36 mV at the first and second oxidation peaks, respectively, relative to those at the catalyst prepared by the impregnation method. The effect of varying methanol concentration on the resulting oxidation current density of Pt-CuO/C electrocatalysts was studied. Some kinetic information about the reaction order with respect to methanol and Tafel slope values was calculated. Slower current density decay was observed in the chronoamperogram of Pt-CuO/C electrocatalyst, prepared by the microwave method, reflecting a lower degree of surface poisoning. Copyright
Full-text · Article · Dec 2012 · International Journal of Hydrogen Energy
[Show abstract][Hide abstract] ABSTRACT: This article reviews the progress made in the past 5 years in the field of direct and non-enzymatic electrochemical sensing of glucose. Following a brief discussion of the merits and limitations of enzymatic glucose sensors, we discuss the history of unraveling the mechanism of direct oxidation of glucose and theories of non-enzymatic electrocatalysis. We then review non-enzymatic glucose electrodes based on the use of the metals platinum, gold, nickel, copper, of alloys and bimetals, of carbon materials (including graphene and graphene-based composites), and of metal-metal oxides and layered double hydroxides. This review contains more than 200 refs.
This article reviews the history of unraveling the mechanism of direct electrochemical glucose oxidation and the attempts to successfully develop non-enzymatic electrochemical glucose sensors over the past 5 years.
Full-text · Article · Feb 2012 · Microchimica Acta