Oral zinc sulfate treatment for viral warts: An open-label study

Department of Dermatology, School of Medicine, Pusan National University Medical Research Institute, Pusan National University, Busan, Korea.
The Journal of Dermatology (Impact Factor: 2.25). 11/2010; 38(6):541-5. DOI: 10.1111/j.1346-8138.2010.01056.x
Source: PubMed


Viral warts, which are caused by the human papilloma virus, are a common problem in dermatology. Various modalities have been used to treat warts, but none are uniformly effective or directly antiviral. Recent studies show that oral zinc sulfate could be effective in the treatment of viral warts. Thirty-one patients with multiple, non-genital viral warts were recruited in this open-label clinical study. The patients were treated with oral zinc sulfate (10 mg/kg to a maximum dose of 600 mg/day) for 2 months and followed up with assessments for the resolution of their warts and for any evidence of recurrence after treatment. Among the 31 patients, 18 patients showed low serum zinc levels (58%). Of 26 patients who completed the study (84%), 13 (50%) showed complete resolution of their warts after 2 months of treatment. Complete responders remained free of lesions at 6-month follow-up. No serious side-effects were reported apart from nausea (16%), mild gastric pain (3%) and itching sensation (3%). Oral zinc sulfate was found to be a good option in the treatment of viral warts, as it was safe and effective without important side-effects.

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    • "A complete cure was observed after 3 months in 50% patients with common warts in zinc oxide group as compared to 42% in the other group. Oral zinc sulphate (10 mg/kg/day) given for 2 months in common warts also resulted in complete clearance in 61% patients in one month and 87% after two months of therapy in a placebo controlled trial by Al-Gurairi et al. [8], whereas clearance rate was 50% with the same dose of oral zinc sulphate after 2 months in an open-label clinical study by Mun et al. [9]. Oral zinc (10 mg/kg/day) has been reported to clear recalcitrant warts in a patient with epidermodysplasia verruciformis in 12 weeks [10]. "
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    ABSTRACT: Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. Topical preparations like zinc oxide, calamine, or zinc pyrithione have been in use as photoprotecting, soothing agents or as active ingredient of antidandruff shampoos. Its use has expanded manifold over the years for a number of dermatological conditions including infections (leishmaniasis, warts), inflammatory dermatoses (acne vulgaris, rosacea), pigmentary disorders (melasma), and neoplasias (basal cell carcinoma). Although the role of oral zinc is well-established in human zinc deficiency syndromes including acrodermatitis enteropathica, it is only in recent years that importance of zinc as a micronutrient essential for infant growth and development has been recognized. The paper reviews various dermatological uses of zinc.
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    ABSTRACT: The elderly are more prone to virus infections and neoplasias than are young adults, During a virus infection, interferon-alpha (IFN-alpha), proteins with antiviral, antiproliferative, and immunomodulatory properties, are transiently expressed, We here report that peripheral white blood cells from 16 subjects with a mean age of 72 years yielded less IFN when stimulated with a virus in vitro than those from 16 young adults with a mean age of 28 years, Monocytes are the main source of this IFN. However, yields of another monocyte product, interleukin-6 (IL-6), were greater in cells from the older subjects than from the young adults, so there is no general defect in monocytes from the former. Immunodeficiency in the elderly has been reported to be associated with a deficiency of zinc, When cultures of white blood cells from the elderly were supplemented with 15 mu M zinc (the physiologic concentration), they produced IFN in amounts comparable to those from the younger subjects.
    No preview · Article · Aug 1997 · Journal of Interferon & Cytokine Research
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    ABSTRACT: Background Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of the patients. Sometimes the disease is difficult to treatment, and also, the relationship between HPV and some forms of skin cancers is important. The cutaneous oxidative stress status of warts is absent in the literature. Objectives To evaluate the role of oxidative stress in affected skin areas in a group of patients with plantar warts. Methods Thirty-six consecutive patients with a diagnosis of plantar warts were enrolled. The samples were obtained by scraping the skin surface. Superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) levels were measured spectrophotometrically at samples. Results The SOD activity was significantly lower, and the MDA level was significantly higher on the lesional area than on the non-lesional area (P < 0.001 for each), and there was no significant difference in the CAT activity between both areas (P = 0.11). Conclusion Cutaneous oxidative stress in patients with plantar warts may play a role in pathogenesis of the disease. The addition of topical drugs with antioxidative effects may be valuable in the treatment of warts.
    No preview · Article · Jan 2012 · Journal of the European Academy of Dermatology and Venereology
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