Functional Specialization of Interleukin-17 Family Members

Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan.
Immunity (Impact Factor: 21.56). 02/2011; 34(2):149-62. DOI: 10.1016/j.immuni.2011.02.012
Source: PubMed


Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets.

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Available from: Yoichiro Iwakura
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    • "IL-17A and IL-17F secreted by Th17 subset are 2 highly homologous pro-inflammatory cytokines and belong to IL-17 family which consists of six subtypes: IL-17A, IL-17B, IL-17C, IL-17D, IL17E and IL-17F[16]. Since their high degree of homology, IL-17A and IL-17F bind the same receptor complex which is comprised of IL-17RA and IL-17RC and consequently exhibits similar biological activities in many aspects[17,18]. Both IL-17A and IL-17F can form disulfide-bonded IL-17AA, IL-17FF homodimers and IL-17AF heterodimer. "
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    Full-text · Article · Jan 2016 · PLoS ONE
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    • "Among them, IL-17A and IL-17F share the highest sequence homology and have similar biological functions. Both bind to IL-17RA and IL-17RC chains [1]. IL-17 is primarily secreted by T helper (Th) 17 cells and innate lymphocytes (í µí»¾í µí»¿ T cells, natural killer (NK) cells, and innate lymphoid cells) [2]. "
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    Full-text · Article · Dec 2015 · Mediators of Inflammation
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    • "IL-17 is the dominant pro-inflammatory cytokine produced by Th17 cells. It has pleiotropic effects such as inducing the release of other cytokines that lead to proinflammatory processes and neutrophil-mobilization [3]. IL-23 and IL-17 have been implicated in the pathogenesis of many autoimmune diseases, such as inflammatory bowel diseases, psoriatic arthritis, and spondyloarthritis [4e6]. "
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