Standing Guard at the Mucosa

ArticleinImmunity 34(2):146-8 · February 2011with4 Reads
Impact Factor: 21.56 · DOI: 10.1016/j.immuni.2011.02.014 · Source: PubMed


    Most successful vaccines elicit antibodies that protect against infection. In this issue of Immunity, Bomsel et al. (2011) show in the rhesus macaque model that vaccine-induced mucosal antibodies, rather than circulating neutralizing antibodies, may be critical components for protective immunity against HIV-1.