Journal of Cardiology (2011) 57, 354—359
available at www.sciencedirect.com
journal homepage: www.elsevier.com/locate/jjcc
Aortic stiffness is strikingly increased with age ≥50
years in clinically normal individuals and preclinical
patients with cardiovascular risk factors: Assessment
by the new technique of 2D strain echocardiography
Yoshifumi Oishi (MD, FJCC)
, Hirokazu Miyoshi (MD), Yukio Mizuguchi (MD),
Arata Iuchi (MD, FJCC), Norio Nagase (MD), Takashi Oki (MD, FJCC)
Cardiovascular Section, Higashi Tokushima Medical Center, National Hospital Organization, 1-1 Ohmukai-kita, Ohtera, Itano,
Tokushima 779-0193, Japan
Received 30 September 2010; received in revised form 7 December 2010; accepted 15 December 2010
Available online 17 February 2011
Background: Various measures of aortic stiffness have been proposed as cardiovascular risk
markers, but interest has now shifted to more direct and easier evaluation of aortic function.
The present study was conducted to determine the feasibility of measuring aortic stiffness
(ˇ) with two-dimensional (2D) strain echocardiography and the impact of age and gender on
Methods and results: The peak circumferential strain of the abdominal aorta was measured
using 2D strain echocardiography, and ˇ was determined in 54 clinically normal individuals and
104 patients with cardiovascular risk factors and no evidence of cardiovascular disease. The ˇ
correlated signiﬁcantly with age in all 158 patients. However, the relationship was nonlinear,
and ˇ was markedly greater in patients ≥50 years. In 54 clinically normal individuals, the
relationship was comparatively linear. The systolic blood pressure and pulse pressure were
signiﬁcantly greater in patients ≥50 years. There were no signiﬁcant differences in ˇ and blood
pressure parameters between genders.
Conclusions: The ˇ increased dramatically with advanced age (≥50 years), regardless of gender,
in clinically healthy and community-based patients with cardiovascular risk factors. The aortic
circumferential strain was measured with 2D strain echocardiography which is a new tool that
can be used to directly and easily evaluate aortic stiffness.
© 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Corresponding author. Tel.: +81 88 672 1171; fax: +81 88 672 3809.
E-mail address: firstname.lastname@example.org (Y. Oishi).
0914-5087/$ — see front matter © 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.