Acute renal failure and disseminated intravascular coagulation associated with rifampin in tuberculosis treatment

Division of Infectious Diseases, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
The International Journal of Tuberculosis and Lung Disease (Impact Factor: 2.32). 03/2011; 15(3):421.
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    • "Although rare (occurring in 0.1% of patients with tuberculosis ), rifampicin-induced acute renal failure may occur as a complication during treatment [1]. Many studies report that this complication is most common in cases where the drug is re-administered or used intermittently [2] [3] [4]. The outcome is usually favorable after discontinuation of the drug, with 96% of patients achieving full recovery within 90 days from onset of renal injury [2]. "
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    ABSTRACT: Rifampicin is a widely used anti tuberculosis agent. On rare occasions, the drug can cause adverse effects such as acute renal failure, though most regain complete renal function upon discontinuation of therapy. The following case report describes a 38 year old Hispanic male presenting with pulmonary tuberculosis who developed rifampicin-induced renal toxicity. He recovered renal function upon discontinuation of the medication without the use of corticosteroids.
    Full-text · Article · Oct 2015
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    • "Renal tuberculosis usually presents as gross haematuria, insidious pyuria, or obstructive uropathy but can also present rarely with acute renal failure in HIV patients with tuberculosis treated with rifampicin [3] [4] [5]. To our knowledge, only one case of tuberculous granulomatous interstitial nephritis causing acute renal failure and proteinuria has been reported previously [6]. "
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    ABSTRACT: Tuberculosis is a multiorgan disease with varied clinical presentations and is reemerging due to increasing immigration and globalization. We present the case of an immigrant female patient who developed acute renal failure with clinical and biochemical features suggestive of lupus nephritis but with a timely renal biopsy showing caseating granulomata in the renal parenchyma consistent with renal tuberculosis. Despite treatment with antituberculosis treatment and resolution of TB on repeat renal biopsy, she remained haemodialysis dependent. We discuss the diagnostic challenges faced in this presentation and also explore possible differential diagnoses. This rare presentation highlights the importance of renal biopsy in the diagnosis and treatment of acute renal failure and the atypical presentation of tuberculosis.
    Full-text · Article · Feb 2012
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    ABSTRACT: Abstract Rifampicin is a widely used anti-tuberculosis agent. Apart from hepatotoxicity, rifampicin can rarely lead to adverse reactions of immunologic nature such as acute renal failure (ARF). We report the case of 57-year-old previously healthy man under treatment for pulmonary tuberculosis who presented with hemolysis and severe ARF. Rifampicin was discontinued and the patient was treated with fluid repletion, iv furosemide and dialysis therapy. Kidney biopsy revealed acute tubulointerstitial nephritis with no evidence of granulomas. The patient significantly improved and was discharged after 51 days of hospitalization. Clinicians using rifampicin should be aware of this rather uncommon but severe complication.
    No preview · Article · Jul 2013 · Renal Failure