Primary intracerebral Hodgkin lymphoma with recurrence

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Clinical neuropathology (Impact Factor: 1.53). 03/2011; 30(2):75-9. DOI: 10.5414/NPP30075
Source: PubMed


To report a case of primary intracerebral Hodgkin lymphoma with disease recurrence.
Case report and review of the literature.
A 58-year-old immunocompetent male presented with aphasia. Neuroimaging revealed a left temporal lobe lesion. A craniotomy and resection were performed, and the diagnosis of classical Hodgkin lymphoma was made. Systemic work-up for lymphoma was negative. Postoperatively, the patient was treated with whole brain irradiation. 14 months later, the patient developed an enhancing lesion in his pons and received combination chemotherapy and radiation therapy. Repeat imaging demonstrated leptomeningeal enhancement and multiple lesions throughout the cerebral hemispheres, cerebellum and brainstem.
We report what appears to be the first case of a patient with aggressive primary intracerebral Hodgkin lymphoma with disease recurrence.

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